血清中Pre-S1与HBeAg联合检测乙型肝炎的临床意义

clinical significance of union examine of Pre-S1 and HBeAg in serum of hepatitis B patient

目的:探讨乙型肝炎病毒前S1抗原(Pre-S1)与HBeAg在乙型肝炎患者血清中的表达情况,评价其联合检测的意义。方法:采用酶联免疫吸附试验(ELISA)对1315例HBsAg阳性患者血清标本进行乙型肝炎(HBV)标志物Pre-S1、HBeAg检测,分析其相互关系。结果:在乙型肝炎的三种血清学模式①(HBsAg、HBeAg、HBcAg)、②(HBsAg、HBeAb、HBcAg)、③(HBsAg、HBcAb)中,Pre-S1的阳性率分别为96.55%、74.19%和42.3%。结论:联合检测Pre-S1和HBeAg在乙型肝炎的临床诊断中具有一定的价值。

Objective： To investigate the value of union examine of Pre-S1 and HBeAg by the condition of them expressed in hepatitis B patient＇s serum.Methods： Enzyme linded immunosorbent assay（ELISA） was adopted to detect PreS1 protein and HbeAg in 1315 cases of serum specimens with positive HBsAg and analyze the relationship of them.Results： The positive rate of Pre-S1 in three patterns of ①（HBsAg、 HBeAg、HBcAg）、②（HBsAg、HBeAb、HBcAg） and ③（HBsAg、HBcAb）were difference（96.55%、74.19% and42.3%）.Conclusion： There was clinical significance in Hepatitis B diagnosis by union examine Pre-S1 and HbeAg.