序贯疗法根除幽门螺杆菌感染疗效观察

Clinical Observation of Using 10-days Sequential Treatment for Helicobacter Pylori Eradication

目的:对比10d序贯疗法与传统三联疗法根治幽门螺杆菌(HP)感染的临床疗效与安全性。方法:选取67例1月内14C尿素呼气试验阳性或者胃镜HP试验阳性病例,随机分为两组:治疗组前5d予兰索拉唑、阿莫西林,后5d予兰索拉唑、替硝唑、克拉霉素治疗;对照组予兰索拉唑加阿莫西林、克拉霉素治疗10d。疗程结束1个月后行14C尿素呼气试验检测。结果:治疗组总有效率97.0%,对照组总有效率78.8%,两组疗效比较有非常显著性差异(P<0.01);治疗组14C尿素呼气试验转阴率为94.1%,对照组转阴率为75.8%,两组HP转阴率比较具有显著性差异(P<0.05)。结论:10d序贯疗法治疗HP感染的根治率较传统三联疗法效果好,且副作用少,依从性好,安全可靠。

Objective：To compare the efficacy and safety of 10 days sequential treatment（including omeprazole,amoxillin,clarithromycin and tinidazole） and 10 days traditional trigeminy therapy（including omeprazole,amoxillin and clarithromycin）for the eradication of helicobacter pylori（HP）.Methods：67 Patients with HP positive who were detected by 14C urea breath test or gastroscope HP test were randomly divided into two groups：the therapic group（34 cases） and the control group（33 cases）.The therapic group was treated with lansoprazole,amoxillin at first 5 days,lansoprazole,clarithromycin and tinidazole at the second 5 days：while the control group was treated with lansoprazole,amoxillin and clarithromycin for 10 days.The 14C urea breath test was detected after course of treatment finished in a month.Results：There was significant difference comparing the total effective rate of the therapic group and the control group with the rate is 97.1% to 78.8%（P0.01）.The eradication rate of 10 days sequential therapy was 94.1% and that of control group was 75.7%,and there was significant difference between two groups（P0.05）.Conclusion：10 days sequential therapy is more effective,well-tolerated and with higher rate of eradication than traditional trigeminy therapy.