期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗结核分枝杆菌感染的免疫机制 被引量：1

Immune Mechanism of Mycobacterium tuberculosis Infection
下载PDF
导出
摘要 对宿主利用体内各种细胞与结核分支杆菌的相互作用进行了综述。机体抵抗结核分枝杆菌感染的机制包括特异性免疫和非特异性免疫,参与非特异性免疫的主要有巨噬细胞和γδT细胞,另外,树突状细胞在引发T细胞免疫方面起着关键的作用。由于结核分支杆菌是胞内寄生菌,特异性免疫以细胞免疫为主,主要包括CD4+T细胞免疫和CD8+T细胞免疫。 The article reviewed the interaction between host cells and Macobacterium tuberculosis.The body resistance mechanisms of Mycobacterium tuberculosis involves specific immune and natural immune.Macrophages and γδT cells are the leading roles in the non-specific immune,while dendritic cells play a key role in T cell immunity.Mycobacterium tuberculosis is a kind of intracellar bacterium.CD4＋ and CD8＋ cell immunity are the main forms of resistance to bacterial.
作者 姚翠梅 孙长江 雷连城 韩文瑜
机构地区 吉林大学畜牧兽医学院
出处 《河北科技师范学院学报》 CAS 2011年第1期44-48,共5页 Journal of Hebei Normal University of Science & Technology
关键词 结核病 非特异性免疫 特异性免疫 细胞免疫 Tuberculosis natural immune specific immune cell immune
分类号 R378.911 [医药卫生—病原生物学]
  • 相关文献

参考文献26

  • 1CORBET E L,WATT C J,WALKER N,et al.The growing burden of tuberculosis:global trends trends and interactions with the HIV epidemic[J].Arch Intern Med,2003,163(9):1009-1021.
  • 2World Health Organization.WHO report 2008:global tuberculosis control-surveillance,planning,financing[R].Geneva:World Health Organization,2008.
  • 3MEGHAN E P,RISH K P,DAVID C S,et al.Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-γ-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling[J].J Immunol,2006,176(8):4323-4330.
  • 4LAFUSE W P,ALVAREZ G R,CURRY H M,et al.Mycobacterium tuberculosis and Mycobacterium avium inhibit IFN-gamma-induced gene expression by TLR2-dependent and independent pathways[J].J Interferon Cytokine Res,2006,26 (8):548-561.
  • 5DANIEL D S,DAI G,SINGH G R,et al.The reduced bactericidal function of complement G52deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacteria phagosomes[J].J Immunol,2006,177(7):4688-4698.
  • 6ROOYAKKERS A W,STOKES R W.Absence of complement receptor 3 results in reduced binding and ingestion of Mycobacterium tuberculosis but has no significant effect on the induction of reactive oxygen and nitrogen intermediates or on the survival of the bacteria in resident and interferon-gamma activated macrophages[J].Microb Pathog,2005,39 (3):57-67.
  • 7AURICCHIO G,GARG S K,MARTINO A,et al.Role of macro-phage phospholipase D in natural and CpG-induced antimycobacterial activity[J].Cell Microbiol,2003,5(12):913-920.
  • 8王翠妮,徐薇,熊思东.结核分枝杆菌对巨噬细胞抗原呈递功能的抑制作用[J].微生物与感染,2009,4(3):132-136. 被引量：2
  • 9陈勇,吕合作,胡建国,候彦强,张海峰,李柏青,何海辉.刺激人γδ^+ T细胞增殖的结核杆菌多肽抗原的纯化与活性鉴定[J].细胞与分子免疫学杂志,2003,19(1):86-89. 被引量：13
  • 10HOFT D F,BROWN R M,ROODMAN S T.Bacille Calmette-Guerin vaccination enhances human gamma delta T cell Responsiveness to mycobacteria sug-gestive of a memory-Like phenotype[J].J Immunol,1998,161 (2):1045-1054.

二级参考文献37

  • 1罗永艾.微卡治疗结核病的机制疗效及安全性[J].中国防痨杂志,2002,24(z1):28-29. 被引量：10
  • 2焦新安,焦新安,Richard Lo-man,Pierre Guermonprez,Edith Deriauf,Sophie Burgaud,Brigitte Gicquel,Nathalie Winter,Claude Leclerc,刘秀梵.重组卡介苗诱导T细胞免疫应答的分子、细胞机理研究[J].中国预防兽医学报,2000,22(S1):180-181. 被引量：1
  • 3何维,李刚,林颖,于松涛,刘庆丰,杜桂书,李静,巴德年.病原体抗原刺激的正常人外周血CD4^+T细胞对γδT细胞的影响[J].中国医学科学院学报,1997,19(6):401-408. 被引量：2
  • 4陶昆,卢贤瑜,陈思静,夏长胜.结核菌H37Ra免疫小鼠后机体抗结核细胞免疫功能的研究[J].第三军医大学学报,2006,28(11):1195-1197. 被引量：6
  • 5Raviglione MC. The global plan to stop TB [ J ]. Int J Tuberc Lung Dis, 2006,10 ( 3 ) : 238-239.
  • 6Sutherland JS, Adetifa IM,Hill PC,et al. Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease [ J ] . Eur J Immunol,2009,39 : 1-7.
  • 7Fenhalls G,Stevens L,Bezuidenhout J,et al. Distribution of IFN-y, IL-4 and TNF-α protein and CD8 T cells producing IL-12 p40 mRNA in human lung tuberculous granulomas [ J ]. Immunology, 2002,105 ( 3 ) : 325-335.
  • 8ZhaoY,Wilson D, Matthews S, et al. Rapid elimination of toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling [ J ]. Infect Immun ,2007,75 ( 10 ) : 4799-4803.
  • 9Rosas LE, Snider HM, Barbi J, et al. Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani[ J]. J Immunol,2006,177 (4) :22-25.
  • 10Parrish, NM, Dick JD, Bishai WR,et al. Mechanisms of latency in Mycobacterium tuberculosis [ J ] . Trends Microbiol, 1998,6 (4) : 107-112.

共引文献38

同被引文献7

引证文献1

二级引证文献8

河北科技师范学院学报
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部