阿司匹林联合氯吡格雷对冠脉支架术后患者的疗效性与安全性研究

Efficacy and Safety of Aspirin Combined with Clopidogrel for Patients with Percutaneous Coronary Intervention

目的探讨阿司匹林和氯吡格雷在冠脉支架术后联合应用的疗效性与安全性。方法将行冠脉支架术的125例急性冠脉综合征(ACS)患者随机分为联合用药组(A组,n=63)和阿司匹林组(B组,n=62)。观察两组患者主要心血管事件(心血管性死亡、心肌梗死、靶血管再通治疗、卒中)及抗血小板药物副作用(出血、皮疹、胃肠道反应)的发生率。结果联合用药组发生2例心血管事件(心肌梗死1例、靶血管再通治疗1例),阿司匹林组发生10例心血管事件(心血管性死亡1例、心肌梗死1例、靶血管再通治疗8例),两组间差异有统计学意义(P<0.05);两组抗血小板副作用的发生率间差异无统计学意义(P>0.05)。结论冠脉支架术后联合使用阿司匹林和氯吡格雷18个月安全、有效,可减少冠脉支架术后心血管事件的发生,出血并发症无明显增加。

Objective To investigate the efficacy and safety of aspirin combined with clopidogrel in patients with percutaneous coronary intervention（PCI）.Methods All 125 acute coronary syndrome（ACS） patients with percutaneous coronary intervention with were randomly divided into combination group（63 cases） and aspirin group（62 cases）.The incidence of major cardiovascular events（cardiovascular death,myocardial infarctions,re-building operation of blood flow for target vessel,apoplexy） and the side reaction of anti-platelet therapy（bleeding,skin rash,gastrointestinal uncomfortable） were observed.Results There were 2 cases of cardiac events in the combination group（1 case of myocardial infarctions,1 case of re-building operation of blood flow for target vessel）,and in the aspirin group there were 10 cases of cardiac events（1 case of cordial death,1 case of myocardial infarctions,8 cases of re-building operation of blood flow for target vessel）,there was a significant difference between the two groups（P0.05）;there was no significant difference in the side reaction of anti-platelet therapy between the two groups（P0.05）.Conclusion The administration of aspirin combined with clopidogrel（less than 18 months） of after percutaneous coronary intervention is safe and effective.It can reduce the occurrence of cardiovascular events after PCI operation,with no obvious increase of hemorrhage complication.