氧气驱动雾化吸入布地奈德治疗新生儿毛细支气管炎

Curative Effect of Budesonide Suspension by Oxygen-driven Nebulization on Neonatal Capillary Bronchitis

目的观察布地奈德混悬液氧气驱动雾化吸入治疗新生儿毛细支气管炎的疗效。方法选2008年11月-2010年11月开封市儿童医院新生儿科收治的65例新生儿毛细支气管炎。随机分成对照组32例和观察组33例;入院后除均给予综合治疗外,观察组加用布地奈德混悬液氧气驱动雾化吸入治疗,疗程5-7 d。结果观察组治愈30例（90.9%）,对照组为23例（71.9%）,两组比较差异有统计学意义（χ2=3.91,P〈0.05）;在喘憋、哮鸣音、湿啰音、咳嗽消失方面差异有统计学意义（t=3.622,4.070,2.590,4.401,P〈0.01、P〈0.01、P〈0.05、P〈0.01）。结论布地奈德混悬液氧气驱动雾化吸入治疗新生儿毛细支气管炎临床疗效好,副作用小,使用安全。

Objective To observe the curative effect of Budesonide suspension by oxygen-driven nebulization in treating neonatal capillary bronchitis.Methods Sixth newborns with capillary bronchitis in the neonatal department of our hospital from November 2006 to March 2010 randomly divided into two groups：32 cases in control group and 33 cases in the experimental group.Both groups were given comprehensive treatment,while the experimental group received addtional Budesonide suspension by oxygen-driven nebulization for 5-7 days.Results Thirty cases in experimental group were cured（90.9%） and 23 cases in control group were cured（71.9%）,and the difference in the curative rate was statistical significance（χ2=3.91,P0.05）;While the difference in disappear of breath holding symptom,wheezing sound,moist rale and cough were statistical significance（t=3.622,4.070,2.590,4.401,P0.01,P0.01,P0.05,P0.01）.Conclusion With less side effect and higher safety,Budesonide suspension by oxygen-driven nebulization is effective for neonatal capillary bronchitis.