高血压合并高尿酸血症患者的治疗药物选择

Treatment Option to Hypertensive Patients with Complicated Hyperuricaemia

目的比较氯沙坦与氨氯地平治疗老年高血压合并痛风患者的疗效。方法将2009年5月至2010年3月期间收治的高血压合并痛风患者64例,随机分为两组,一组口服氯沙坦50mg/d,另一组给予氨氯地平5mg/d,治疗6周。观察患者服药后舒张压(DBP)、收缩压(SBP)、血清尿酸等指标的变化。结果治疗6周后,氯沙坦与氨氯地平都能有效降压和降低血尿酸水平(P<O.05),氯沙坦治疗组降压总有效率低于氨氯地平治疗(氯沙坦治疗组为84.38%,氨氯地平组为93.75%,P<O.05);氯沙坦组血清尿酸水平下降程度高于氨氯地平组(P<O.05)。结论氯沙坦与氨氯地平均可用于高血压合并高尿酸血症的治疗,氯沙坦降尿酸的疗效优于氨氯地平。

Objective： To evaluate the effect of losartan compared with amlodipine valsartan on blood pressure and serum uric acid（SUA）level in essential hypertensive patients with hyperuricaemia.Methods： 64 essential hypertensive patients with hyperuricaemia randomly divided into losartan group（n=32,treated with losartan 50 mg/d）and amlodipine group（n=3,treated with amlodipine 5 mg/d）.The SUA concentration and blood pressure were measured at baseline after 6 weeks treatment.Results： After treatment with losatan or amlodipine for 6 weeks,blood pressure and the lever of SUA were markedly decreased in both groups（PO.05）.However,in decreasing blood pressure,amlodipine is better than losatan（PO.05）;in deducing SUA,the effects of losartan is better than amlodipine（PO.05）.Conclusion： Losartan is a good choice for patients with hypemricemia complicated with hypertension.