急性有机磷中毒治疗中阿托品用量的影响因素分析

Influences of the Atropine Dosage Factors in the Organ Phosphorus Intoxication

目的探讨急性有机磷中毒中影响阿托品用量的相关因素。方法用主成份分析的方法分析了影响阿托品用量的相关因素：服药至来院时间（分钟）、中毒症状、服药种类、服药剂量（ml）、洗胃次数、入院时测定胆碱酯酶数值IU／L（入院24h内最低值）、复能剂使用量（氯磷定）、阿托品化时阿托品用量缸圆。结果建立了预测阿托品使用总量的模型。结论阿托品化时阿托品用量是影响使用总量的最重要的影响因素，准确地掌握使用方法和用量是救治的关键。也是防范阿托品中毒的重要措施。

Objective To discuss the related influencing factors of the atropine dosage. Methods To analyze the related factors which can influence the atropine dosage with way of principal component analysis. The factors ：the intervals of time （minute） between taking organ phosphorus pesticide and seeing doctor, the symptom ,the sort of organ phosphorus pesticide ,the dose of organ phosphorus pesticide （ml）,the times of gastric average, the quantitative value of cholinesterase （IU/L）（the minimum in 24 hours）,the dosage of cholinesterase reactivator （pyraloxime methyl chloride） and the atropine dosage when the patient is getting atropinization （mg）. Results The model which can be used to dope out the atropine dosage is be founded. Conclusion The atropine dosage when the patient is getting atropinization is the most important influencing factor of the total dosage of atropine. The accurate using method and dosage of atropine is the key to the treatment and is the important protective measure of atropism.