氨基酯交换法合成苯氨基甲酸甲酯

Synthesis of Methyl N-phenyl Carbamate by Amino-transesterification

以PbO经甲醇预处理获得的甲氧基铅为催化剂,苯胺(AN)与氨基甲酸甲酯(MC)为原料酯交换合成苯氨基甲酸甲酯(MPC)。考察了甲醇用量、温度、时间、催化剂用量及原料配比等条件对合成反应的影响。结果表明,m(甲醇)/m(MC)=2、反应温度为150℃、反应时间为5 h、催化剂用量为原料总量的0.1%、m(MC)/m(AN)=2时,MPC的收率可达97.5%,选择性为97.86%。

In the presence of Pb（OCH3）2 catalyst,synthesis of methyl N-phenyl carbamate（MPC） from aniline and methyl carbamate by amino-transesterfication was discussed.The effects of methanol dosage,reaction temperature,reaction time,catalyst dosage and the mass ratios of methyl carbamate to anline on the reaction were studied,and the reaction mechanism over lead methylate catalyst was proposed.Under the optimum reaction conditions,the yield of MPC reached 97.5% and selectivity of MPC is 97.86%.