血管紧张素转化酶2基因多态性与原发性高血压的关系

Relationship between angiotensin-converting enzyme 2（ACE2） G8790A polymorphisms and essential hypertension

目的研究血管紧张素转化酶2基因（ACE2-G8790A）单核苷酸多态性（SNP）与原发性高血压的关系。方法用PCR—RFLP及电泳分析法进行基因分型，SPSS软件分析各等位基因与原发性高血压的相关性。结果高血压患者与对照组的基因型、等位基因频率比较均有显著性差异（P=0．020，0．001）。高血压组GG、GA和AA基因型在女性中的分布频率分别为29．2％、42．4％和28．4％，女性对照组相应基因型的频率分别为29．3％、56．6％和14．1％，两组比较有显著性差异；G，A等位基因频率在高血压组分别为53．0％和47．0％，对照组相应的等位基因频率为63．3％，36．7％，两组比较差异有显著性（P〈0．01）。结论ACE2-G8790A基因多态性与原发性高血压相关。

Objective To study the relationship between ACE2-G8790A SNP and essential hypertension. Methods Genotyping of ACE2-G8790A was detectedwith PCR-RFLP and agarose gel electrophoretic analysis. All statistical analyses were performed by using SPSS for Windows. Results 318 patients with essential hypertension （ EH ） and 233 healthy controls were studied. Significant difference in genotypic and allelic frequency of G8790A SNP in ACE2 between EH patients and controls were found（P =0.020, and 0. 001 respectively）. Frequencies of GG, GA, AA Genotypes in female were 29. 2% , 42.4% ,28.4% in essential hypertension group,while 29.3% , 56.6% ,14.1% in controls. Frequencies of G,A were 53.0% ,47.0% in essential hypertension group and 63.3% ,36.7% in controls. Conclusions Genetic variants of G8790A of ACE2 were association with essential hypertension.