注射用氯诺昔康与盐酸氯胺酮注射液在0.9%氯化钠注射液中的稳定性考察

Stability and Compatibility of Lornoxicam with Ketamine Hydrochloride in 0.9%Sodium Chloride Injection

目的:考察注射用氯诺昔康与盐酸氯胺酮注射液在0.9%氯化钠注射液中的稳定性。方法:采用高效液相色谱法,测定注射用氯诺昔康与盐酸氯胺酮注射液配伍后在室温条件下72h内的含量变化,并观察和检测配伍液的外观及pH变化。结果:配伍液中盐酸氯胺酮含量与pH无明显变化,氯诺昔康的含量逐渐降低,配伍液24h后出现少量沉淀。结论:室温条件下,注射用氯诺昔康与盐酸氯胺酮注射液在0.9%氯化钠注射液中不稳定,临床不宜配伍应用。

Objective ： To study the stability and compatibility of lornoxicam with ketamine hydrochloride in 0. 9% sodium chloride injection. Method ： The content changes of lornoxicam and ketamine hydrochloride were determined simultaneously by HPLC, and pH value and the solution appearance were observed within 72 hours. Result： No significant differences were found in pH value and the content of ketamine hydrochloride, while the content of lornoxicam ever - decreased and a bit of precipitation presented after 24 hours mixing. Conclusion ： The mixture of lornoxicam and ketamine hydrochloride in 0. 9% sodium chloride injection at ambient temperature was not stable, suggesting unfitness for clinical application.