摘要
目的:考察盐酸法舒地尔与奥扎格雷钠注射液的配伍稳定性。方法:采用HPLC法测定室温(25℃)条件下配伍溶液放置8 h两药的含量变化,并考察配伍前后外观、性状、pH及不溶性微粒的变化。结果:注射用盐酸法舒地尔与奥扎格雷钠配伍后在室温下放置8 h,配伍溶液的外观、性状、pH及不溶性微粒无明显变化,两药的含量仍在97%以上。结论:盐酸法舒地尔注射液与奥扎格雷钠注射液配伍8 h内未发现明显变化。
Objective： To study the compatibility of fasudil hydrochloride injection and ozagrel sodium injection. Method： The changes in pH value, external appearance and insoluble particles of the two preparations were observed and their relative contents were determined by HPLC within 8 h after the compatibility at room temperature. Result： There were no significant changes in all the tested indices of the two preparations in 8 h after the compatibility. The relative contents were both above 97% at the end of the experiment. Conclusion： There are no significant changes in fasudil hvdrochloride injeetion and ozagel sodium injection in 8 hour compatibility.
出处
《中国药师》
CAS
2011年第6期827-828,共2页
China Pharmacist
