Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery

共聚物 mPEG 打印机控制语言被准备并且 grafted 到 polyethylenimine (PEI ) 上综合有低 cytotoxicity 的共聚物 mPEG-PCL-g-PEI。mPEG-PCL-g-PEI 能压缩与积极希腊语的第六个字母潜力形成 nanoparticles 的 siRNA。这些 nanoparticles 能交货 siRNA 进基因，它建议了那 mPEG-PCL-g-PEI 能为 siRNA 作为高度有效的向量服务有效地禁止目标的表示的房间交货。

Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine（PEI） to synthesize copolymers mPEG-PCL-g-PEI with low cytotoxicity.The mPEG-PCL-g-PEI could condense siRNA to form nanoparticles with positive zeta potential.These nanoparticles could delivery siRNA into cells to effectively inhibit the expression of target gene,which suggested that mPEG-PCL-g -PEI could serve as a highly efficient vector for siRNA delivery.