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AMI患者血浆NT-proBNP水平与心肌缺血及预后关系的研究 被引量:2

Relationship between Plasma NT-proBNPLevels and Myocardial Ischemia and Prognosis in AMI Patients
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摘要 目的:探讨急性心肌梗死(AMI)患者血浆N末端B型尿钠肽前体(NT-proBNP)的水平与心肌缺血及预后的关系。方法:98例急性心肌梗死患者根据患者是否行直接PCI手术治疗,分为PCI手术治疗组和非PCI治疗组,观察缺血改善情况与NT-proBNP水平的关系,同时根据治疗后NT-proBNP的水平分为三组,A组NT-proBNP<125pg/ml、B组125pg/ml≤NT-proBNP<450pg/ml、C组NT-proBNP≥450pg/ml,观察NT-proBNP的水平与预后的关系。结果:行PCI组NT-proBNP的水平下降程度(438.3±134.5)明显高于未行PCI组者(158.6±146.1,P<0.05),MACE的发生情况C组明显高于A组(P=0.006<0.01),也高于B组(P=0.028<0.05),A组与B组相比,B组的MACE发生率有上升的趋势,但是无统计学意义(P=0.432>0.05)。结论:急性心肌梗死患者早期血浆NT-proBNP的水平在一定程度上可以反应心肌的缺血程度,且与患者的预后成明显的负相关。 Objective: To study the relationship between plasma N-terminal pro-B-type natriuretic (NT-proBNP) levels and myocardial ischemia, prognosis in Acute myocardial infarction (AMI) patients. Methods: According to the patients whether underwent primary PCI operation ,98 AMI patients were divided into surgical PCI treatment group and the non-PCI treatment group, to observe the association improved schemia situation with NT-proBNP level, meanwhile according to the levels of the NT-proBNP after treatment ,the patients were divided into three groups, including A group(NT-proBNP〈 125pg/ml), B group (125pg/ml ≤NT-proBNP〈450pg/ml) and C group (NT-proBNP≥450pg/ml), to observe the relationship between the levels of the NT-proBNP and prognosis. Results: The NT-proBN- P levels in PCI treatment group decreased significantly (438.3±134.5)compared with non-PCI treatment group (158.6± 146.1, P 〈0.05), The incidence of MACE in group C was significantly higher than group A (P = 0.006 〈0.01), also higher than the B group(P=-0.028 〈 0.05 ), The incidence of MACE in group B was higher than group A, but the two groups no significant difference in meaning. Conclusions: AMI patients with early plasma NT-proBNP levels Can reflect the degree of myocardial ischemia to some extent, and have a significant negative correlation to prognosis of the patient.
出处 《现代生物医学进展》 CAS 2011年第13期2519-2521,共3页 Progress in Modern Biomedicine
关键词 心肌梗死 NT-PROBNP 心肌缺血:预后 AMI N-terminal pro-B-type natriuretic Myocardial ischemia Prognosis
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  • 1McCullough PA, Sandberg KR. Sorting out the evidence on natriuretic peptides[J]. Rev Cardiovasc, 2003, 4: S13-S19.
  • 2Darbar D, Davidson NC, Gillespie N, et al. Diagnostic value of B-type Natriuretic Peptide concentrations in Patients with acute myocardial infarction[J]. Am J Cardiol, 1996, 78:284-287.
  • 3Hama N, Itoh H, Shirakami G, et al. Rapid ventricular induction of BNP gene expression in experimental acute myocardial infarction[J]. Circulation, 2005, 92(6): 1558-1564.
  • 4王瑶,陶则伟,陆贤,黄元伟.B型钠尿肽的研究进展[J].心脏杂志,2003,15(6):555-557. 被引量:41
  • 5赵世平,曹秀华,张丽娜.NT-proBNP在急性冠脉综合征中的研究[J].放射免疫学杂志,2008,21(1):79-82. 被引量:8
  • 6Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and mangement of chronic heart failure in the adult: a report of the American College If Cardiology/American Heart Association Task Force on Practice Guidelines [J]. Circulation, 2005, 112 (12): 154-235.
  • 7Mccullough PA, Omland T,Maisel AS. B-type natriuretic peptides:a diagnostic breakthrough for clinicians [J].Rev Cardiovasc Med.2003,4 (2):72-80.
  • 8De lemosJ,Morrow DA. Brain natriuretic peptide measurement in acute coronary syndromes: ready for dinical application[J]. Circulation, 2002, 108:833.
  • 9Omland T, de Lemos JA, Morrow DA, eta l. Prognostic value of N-terminal pro-atrial and pro-brain natriuretic pepfide in patients with acute coronary syndromes[J]. Am J Cardiol, 2002, 89:463-465.
  • 10Arakawa N, Nakamura M, Aoki H, et aI. Plasma brain natriuretic peptide concentrations predict survival after acute myocardia infarction [J]. Jam Coil Cardiol, 1996, 27:1656-1661.

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  • 1赵瑞平,王飞.急性心肌梗死患者再灌注治疗后不同胰岛素水平对其预后的影响[J].中华临床医师杂志(电子版),2011,5(11):3317-3319. 被引量:2
  • 2张宝宁,张磊,雷军荣,何勇,蔺军芳,张卫达,王晓武.法洛四联症根治术117例[J].第四军医大学学报,2006,27(5):480-480. 被引量:9
  • 3Kirchberger I, Heier M, Kuch B, et al. Presenting symptoms of myocardial infarction predict short-and long-term mortality: The MONICA/KORA Myocardial Infarction Registry [J]. Am Heart J, 2012, 164(6): 856-861.
  • 4Armas NB, Ortega YY, Suarez R, et al. Early acute myocardial infarction mortality in cuba, 1999-2008 [J]. MEDICC Rev, 2012, 14 (4): 19-25.
  • 5Angtuaco MJ,Sachdeva R,Jaquiss RD. Long-term outcomes of intraoperative pulmonary artery stent placement for congenital heart disease[J].{H}Catheterization and Cardiovascular Interventions,2011,(3):395-399.
  • 6Moustafa S,Merchant N,Prieur T. Unusual operation for tetralogy of fallot[J].Arch Cardiovasc Dis,2013,(3):180-181.
  • 7Hata T,Mashima M,Ito M. Three-Dimensional HDlive Rendering Images of the Fetal Heart[J].{H}Ultrasound in Medicine & Biology,2013,(13):662-665.
  • 8Polito A,Piga S,Cogo PE. Increased morbidity and mortality in very preterm/VLBW infants with congenital heart disease[J].{H}Intensive Care Medicine,2013,(6):1104-1112.
  • 9Guihaire J,Haddad F,Mercier O. The Right Heart in Congenital Heart Disease,Mechanisms and Recent Advances[J].J Clin Exp Cardiolog,2012,(10):1-11.
  • 10Ruggieri F,Gemma M,Calvi MR. Perioperative serum brain natriuretic peptide and cardiac troponin in elective intracranial surgery[J].{H}NEUROCRITICAL CARE,2012,(3):395-400.

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