摘要
目的:探讨急性心肌梗死(AMI)患者血浆N末端B型尿钠肽前体(NT-proBNP)的水平与心肌缺血及预后的关系。方法:98例急性心肌梗死患者根据患者是否行直接PCI手术治疗,分为PCI手术治疗组和非PCI治疗组,观察缺血改善情况与NT-proBNP水平的关系,同时根据治疗后NT-proBNP的水平分为三组,A组NT-proBNP<125pg/ml、B组125pg/ml≤NT-proBNP<450pg/ml、C组NT-proBNP≥450pg/ml,观察NT-proBNP的水平与预后的关系。结果:行PCI组NT-proBNP的水平下降程度(438.3±134.5)明显高于未行PCI组者(158.6±146.1,P<0.05),MACE的发生情况C组明显高于A组(P=0.006<0.01),也高于B组(P=0.028<0.05),A组与B组相比,B组的MACE发生率有上升的趋势,但是无统计学意义(P=0.432>0.05)。结论:急性心肌梗死患者早期血浆NT-proBNP的水平在一定程度上可以反应心肌的缺血程度,且与患者的预后成明显的负相关。
Objective: To study the relationship between plasma N-terminal pro-B-type natriuretic (NT-proBNP) levels and myocardial ischemia, prognosis in Acute myocardial infarction (AMI) patients. Methods: According to the patients whether underwent primary PCI operation ,98 AMI patients were divided into surgical PCI treatment group and the non-PCI treatment group, to observe the association improved schemia situation with NT-proBNP level, meanwhile according to the levels of the NT-proBNP after treatment ,the patients were divided into three groups, including A group(NT-proBNP〈 125pg/ml), B group (125pg/ml ≤NT-proBNP〈450pg/ml) and C group (NT-proBNP≥450pg/ml), to observe the relationship between the levels of the NT-proBNP and prognosis. Results: The NT-proBN- P levels in PCI treatment group decreased significantly (438.3±134.5)compared with non-PCI treatment group (158.6± 146.1, P 〈0.05), The incidence of MACE in group C was significantly higher than group A (P = 0.006 〈0.01), also higher than the B group(P=-0.028 〈 0.05 ), The incidence of MACE in group B was higher than group A, but the two groups no significant difference in meaning. Conclusions: AMI patients with early plasma NT-proBNP levels Can reflect the degree of myocardial ischemia to some extent, and have a significant negative correlation to prognosis of the patient.
出处
《现代生物医学进展》
CAS
2011年第13期2519-2521,共3页
Progress in Modern Biomedicine