鼻咽癌与miRNAs

Nasopharyngeal carcinoma and miRNAs

鼻咽癌(nasopharyngeal carcinoma,NPC)是一种多基因遗传性疾病,好发生于我国华南、东南亚及部分非洲地区。近年来随着分子生物学及其技术的迅速发展,人们对鼻咽癌发生、发展及其生物学行为的研究已进入基因水平。microRNA(miRNA)是一类广泛存在于动植物体内的非编码小RNA,主要参与基因转录后水平调控。随着对miRNA研究的深入,发现肿瘤的细胞分化障碍、增殖失控、细胞永生化与miRNA密切相关。人类肿瘤组织与正常细胞组织间的miRNA表达水平和类型存在明显差异,提示miRNA可能是一类新的参与肿瘤发生的重要分子。本文就鼻咽癌与miRNA相关的研究进展作一综述。

Nasopharyngeal carcinoma （NPC） is a polygenic disease, and widely prevalent in the southern China, southeast Asia and parts of Africa. In recent years, with the rapid development of molecular biology and technology, the study of mechanism in NPC has entered gene level, microRNAs （miRNAs） are small non-coding RNAs regulation post-transcriptional level. With the depth of miRNA research, tumor cell differentiation, proliferation and immortalization are closely related with miRNAs. The significantly different miRNA profiles between NPC specimens and normal nasopharyngeal epithelium suggest that miRNAs may be a new class of important carcinogenesis molecules. In this paper, the NPC and its related-miRNAs were reviewed.