摘要
磷脂酰肌醇3-激酶(phosphatidylinosito1 3-kinase,PI3K)是体内很多生理过程中起关键作用的信号分子,PI3K介导的信号转导通路调节细胞的增生、分化、凋亡等活动。以往研究较多的是PI3K与肿瘤发生发展的关系,最近很多研究发现PI3K介导的信号转导通路对心脏具有重要的调节功能。本文就近年来关于PI3K的结构和功能以及PI3K对心脏的调节的研究作一综述。
Phosphoinositide 3-kinases (PI3K)plays an important role in cell responses including cell proliferationl,differentiation and apoptosis.In the past, many studies focused on the effects of PI3K on genesis and development of tumor, however ,in recent years, many researches have revealed that PI3K signaling pathway has significant effects on cardiac regulation.ln this review, the structure and function of PI3K and its roles in cardiac regulation will be summarized.
出处
《现代生物医学进展》
CAS
2011年第13期2578-2580,共3页
Progress in Modern Biomedicine