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磷脂酰肌醇3-激酶对心脏的调节 被引量：2

Regulation of Phosphoinositide 3-kinases on the Heart
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摘要 磷脂酰肌醇3-激酶(phosphatidylinosito1 3-kinase,PI3K)是体内很多生理过程中起关键作用的信号分子,PI3K介导的信号转导通路调节细胞的增生、分化、凋亡等活动。以往研究较多的是PI3K与肿瘤发生发展的关系,最近很多研究发现PI3K介导的信号转导通路对心脏具有重要的调节功能。本文就近年来关于PI3K的结构和功能以及PI3K对心脏的调节的研究作一综述。 Phosphoinositide 3-kinases （PI3K）plays an important role in cell responses including cell proliferationl,differentiation and apoptosis.In the past, many studies focused on the effects of PI3K on genesis and development of tumor, however ,in recent years, many researches have revealed that PI3K signaling pathway has significant effects on cardiac regulation.ln this review, the structure and function of PI3K and its roles in cardiac regulation will be summarized.
作者 王玉强 盛净
机构地区 上海交通大学医学院附属第九人民医院老年科
出处 《现代生物医学进展》 CAS 2011年第13期2578-2580,共3页 Progress in Modern Biomedicine
关键词 PI3K/AKT 信号通路 心肌肥大 心衰 PI31GAM Signaling pathway Myocardial hypertrophy Heart failure
分类号 Q55 [生物学—生物化学] R54 [医药卫生—心血管疾病]
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参考文献20

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同被引文献13

  • 1王娟,俞力,范钰.miR-155反义寡核苷酸转染对甲状腺癌细胞迁移、侵袭和MMP-13表达的影响[J].江苏大学学报（医学版）,2013,23(6):526-528. 被引量：3
  • 2秦薇,蔡久英.GH/IGF-1治疗心力衰竭作用机制的研究进展[J].心血管病学进展,2005,26(6):578-581. 被引量：3
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  • 6TANADA Y, SHIOI T, KATO T, et al. Branched- chain amino acids ameliorate heart failure with cardiac cachexia in rats[J]. Life Sci, 2015,137:20--27.
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现代生物医学进展
2011年 第13期

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