血清总胆汁酸对新生儿缺氧缺血性脑病肝损伤的临床意义

The clinical significance of serum total bile acids (TBA) in hypoxia ischemic encephalopathy (HIE) with liver damage of the newborn.

目的探讨血清总胆汁酸(TBA)测定在新生儿缺氧缺血性脑病(HIE)患儿肝脏损伤中的临床意义。方法对120例足月HIE新生儿和30例足月健康新生儿的血清TBA进行测定并动态观察。结果 HIE患儿血清TBA水平明显升高,但轻度HIE患儿血清TBA与正常足月新生儿水平无明显差异(P>0.05),重度HIE患儿血清TBA水平明显高于正常新生儿(P<0.01),经过治疗后TBA水平均较前下降,且具有统计学意义(P<0.01),提示新生儿HIE常有肝脏损害,且随着缺氧严重程度逐渐加重。结论血清TBA测定可以早期、动态反应HIE患儿肝脏损伤情况,是新生儿肝实质损伤的早期诊断指标,对新生儿HIE的预后有一定的指导作用,值得在临床上借鉴、推广。

Objective To explore the clinical significance of serum total bile acids （TBA） in hypoxia ischemic encephalopathy （HIE） of the newborn. Methods The quantity of serum total bile acids were detected in 120 infants with HIE.Results There were no significant differences between the slightly HIE group and the normal group（P〉0.05） while there were significant differences between the severe HIE group and the normal group（P〈0.01）.The TBA level greatly decreased after therapy among the HIE group（P〈0.01）.Conclusion TBA is a better liver function target and an early diagnosis target of reflecting liver essence damage in infants with HIE. It should be popularized in clinical work.