舒芬太尼联合丙泊酚用于人工流产术临床观察

Clinical Observation of Sufentanil and Propofol Used in Artifical Abortion

目的:观察舒芬太尼联合丙泊酚在人工流产术中的麻醉效果和不良反应。方法:自愿接受无痛人工流产手术的育龄妇女200例随机分为舒芬太尼组(S组,n=100)和芬太尼组(F组,n=100),S组先静注舒芬太尼0.1μg·kg^(-1),接着静注丙泊酚1.8 mg·kg^(-1);F组先静注芬太尼1μg·kg^(-1),接着静注丙泊酚2.3 mg·kg^(-1),在患者意识丧失、呼之不应后开始手术。观察两组患者的麻醉诱导时间、丙泊酚用量、清醒时间,收缩压、舒张压、心率、呼吸变化及不良反应发生情况。结果:S组丙泊酚用量明显少于F组,不良反应发生率也明显低于F组(P<0.01)。结论:舒芬太尼联合丙泊酚是较理想的无痛人流术的复合麻醉方法。

Objective ：To observe the effect of anesthesia and the complications of propofol on artificial abortion by using sufentanil and propofol. Method：200 patients willing to accept the painless artificial abortion were randomly divided into two groups ： sufentanil group （ S, n ：= 100） and fentanyl group （ F, n = 100）. The patients of Group S were intravenous- ly injected with suftenail（50 μg diluted with normal saline to 10 ml） 0.1 μg · kg^-1and then with propofol 1.8 mg ·kg^-1. The patients of Group F were intravenously injected with fentanyl （0.1 mg diluted with normal saline to 4 ml） 1 μg · kg^-1 and then with propofol 2.3 mg · kg^- 1. All the patients were operated on when they were unconscious and could not answer when calling them. Their induction time, dose of propofol, changes of SBP, DBP, HR and RR, time of coming back to life and all the complications were observed. Result： The dose of propofol used by Group S was obviously smaller then that used by Groups F and the complication frequency was also much slower. There was obvious difference between the two groups （ P 〈 0.01 ）. Conclusion：The combination of sufentanil with propofol was an ideal anesthesia method in artificial abortion.