331例抗感染药致老年人药品不良反应分析

Analysis of 331 Cases of Anti-infective-induced Adverse Drug Reactions in Elderly Patients

目的:了解抗感染药致老年人药品不良反应(ADR)的情况,分析其相关因素。方法:回顾性调查分析我院2004年1月～2009年12月收集上报的ADR报告中,抗感染药致老年人ADR的特点和规律。结果:抗感染药致老年人ADR共331例,占上报ADR例数的9.87%。涉及抗感染药为14类55个品种,喹诺酮类药物引起的ADR占首位,其中以左氧氟沙星为主;给药途径主要为静脉给药;以皮肤及附件的损害最常见。结论:抗感染药致老年ADR与抗感染药的种类、给药途径、给药剂量等多种因素相关,临床上给老年人使用抗感染药时应注意合理用药,以减少或避免老年人ADR的发生。

Objective：To study the situation of ADRs induced by anti-infective in elderly patients. Metbod：A retrospective investigation was used for 331 cases of anti-infective-induced ADRs in the elderly in our Hospital from January 2004 to December 2009 and their statistics was analyzed. Result： Of all ADRs, 331 cases occurred in the elderly and were induced by anti-infective agents. FQNs were the primary anti-infective agents which induced ADRs in the elderly. The main dosing route of the anti-infective agents was iv injection. The commonest reaction was the damage to skin and its appenda- ges. Conclusion：The ADRs are related to varivety factors such as the category of anti-infective agents route and dose of ad- ministration. Anti-infective anents should be used in elderly rationally.