肝病患者血清甲状腺相关物质的检测与意义

The detection and clinical significance of serum thyroid-related substances in patients with liver diseases

目的探讨不同程度肝病患者血清甲状腺激素水平的变化及其意义。方法应用放射免疫法分别检测114例慢性肝炎、130例肝硬化、96例重型肝炎、120例健康体检者的血清甲状腺激素水平(T3、T4、FT3、FT4、rT3、TSH),抗甲状腺过氧化物酶抗体(抗TPO)、抗甲状腺球蛋白抗体(抗TG)的含量变化。结果肝病患者较正常人血清甲状腺素水平(T3、T4、FT3、FT4)显著降低,而抗TPO、抗TG、rT3含量显著升高,差异有统计学意义;随着肝功能受损程度的加重,血清甲状腺素水平(T3、T4、FT3、FT4)降低程度差异有统计学意义。结论肝病患者血清甲状腺激素水平的检测对评估肝功能、判断病程及预测预后有一定的临床意义。

Objective To investigate the role of serum thyroid-related substances in patients with liver diseases of various degrees.Method Serum levels of thyroid hormones（T3,T4,FT3,FT4,rT3 and TSH）,anti-TPO antibody and anti-TG antibody were measured with radioimmunoassay in 114 patients with chronic hepatitis,130 patients with cirrhosis,96 patients with hepatic failure and 120 healthy subjects.Result Thyroid hormone levels in patients with liver diseases were significantly lower than healthy controls,whereas the anti-TG and rT3 levels were higher in patients with liver diseases.With increased impairment of liver function,the serum thyroid hormones（T3,T4,FT3 and FT4） declined with statistical significance.Conclusion The measurement of serum thyroid-related substances is a helpful tool in evaluating the liver function and the clinical course,as well as the prediction of clinical outcomes.