女性2型糖尿病患者尿路感染病原菌的分布及耐药性监测

Distribution and drug resistance supervision on bacteria in urinary tract infection in female patients with Type 2 diabetes

目的探讨女性2型糖尿病患者尿路感染病原菌的种类及耐药性,为临床合理用药提供科学依据。方法对2009年1月至2011年1月在绍兴市人民医院住院的女性2型糖尿病患者尿路感染病原菌的分布及耐药性进行回顾性分析。结果分离的112株病原菌,以大肠埃希菌为主,占58.9%,其次为肺炎克雷伯菌和真菌,分别为10.7%和8.9%;其中产超广谱β-内酰胺酶(ESBLs)的大肠埃希菌株检出率为40.9%,产ESBLs的肺炎克雷伯菌株检出率为8.3%;大肠埃希菌对碳青霉烯类、头霉素类、丁胺卡那和呋喃妥因的耐药率较低,而肺炎克雷伯菌对多种抗菌药物具有较好的敏感性。结论女性2型糖尿病患者易患尿路感染,病原菌以大肠埃希菌为主,且对多种抗菌药物的耐药率较高,临床应根据药敏结果合理选用抗菌药物。

Objective To explore the species and drug resistance of pathogenic bacteria in urinary tract infection in female patients with Type 2 diabetes and provide scientific basis for clinical rational medication.Method The distribution and drug resistance of pathogenic bacteria in urinary tract infection in Female inpatients with Type 2 diabetes in our hospital from January 2009 to January 2011 was retrospectively analyzed.Result The main pathogenic bacteria from the 112 isolated pathogen strains was Escherichia coli（E.coli） which accounted for 58.9%,followed by Klebsiella pneumoniae and fungi which accounted for 10.7% and 8.9%,respectively.Among them the detection rate of extended spectrum β-lactamase（ESBLs） producing E.coli strains were 40.9%,and that of the ESBLs Klebsiella pneumoniae strains were 8.3%;E.coli showed low drug resistance ratio to carbapenem,cephamycins,amikacin and furadantin,and Klebsiella pneumoniae showed a good sensitivity to most of the antibiotics.Conclusion Female patients with Type 2 diabetes are susceptible to urinary tract infection.The main pathogenic bacteria is E.coli,which have high drug resistance ratio to most of antibiotics.Rational clinical medication should be based on the antimicrobial susceptibility test results.