阿尔茨海默病中Toll样受体与小胶质细胞的关系

Relationship between toll-like receptors and microglia in Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease,AD)是老年人常见的一种神经退行性疾病。目前AD的发病机制还不是很清楚,但大多数学者认为淀粉样蛋白沉积激活神经胶质细胞所导致的炎症反应是其核心病理机制,其中小胶质细胞是主要的炎症细胞。近期研究表明Toll样受体(Toll-like receptor,TLR)在小胶质细胞的激活过程中发挥着一定的作用。本文主要就近年来AD发病过程中TLR与小胶质细胞之间关系方面的研究进行综述。

Alzheimer’s disease（AD） is a common neurodegenerative diseaase in the elderly.The pathogenesis of AD has not been clear now,but most of scholars think the deposition of β-amyloid activated the neuroglial cells,which result in the chronic inflammatory reactivity in AD brain.Microglial cells are one sort of the most important inflammatory cells.Recent research has implicated the effect of Toll-like receptors in the activation of microglia.This paper reviewed the research progress of the relationship between Toll-like receptors and microglia in AD.