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TDAG8介导的细胞内信号传送通路及其功能 被引量：1

TDAG8-mediated intracellular signaling pathways and its function
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摘要 T细胞死亡相关基因8编码的受体蛋白/G蛋白偶联受体65(TDAG8)是G蛋白偶联受体家族成员之一,起初它被鉴定为脂质分子(鞘氨醇半乳糖苷)的受体;后来的研究证明TDAG8也具有感知细胞外的质子或pH的功能。因此,TDAG8是一种特殊的双配体受体。TDAG8受体广泛表达在免疫组织等正常组织和肿瘤组织中,具有潜在的重要生理作用。本文对TDAG8介导的细胞内信号通路及TDAG8功能研究进展进行综述。 TDAG8 is one of the receptors of G protein-coupled receptor family. It has been described as a receptor for lipid molecule psychosine. Subsequent studies indicat that the receptor also sense extracellular proton or pH. Thus, TDAG8 is a special kind of double ligand receptor. Widely expressed in normal tissues such as immune tissue, and tumor tissues, TDAG8 may have some potential physiological functions. In this paper, we reviews the research progress of the TDAG8-mediated intracellular signalling pathways and its function.
作者 杨德志 杨文华 张谦 赵宏凯 阿拉坦高勒
机构地区 内蒙古大学生命科学学院生物系
出处 《生命的化学》 CAS CSCD 北大核心 2011年第3期434-437,共4页 Chemistry of Life
基金 高等学校博士学科点专项科研基金(20091501110001) 内蒙古大学"211工程"创新人才培养项目资助
关键词 TDAG8 鞘氨醇半乳糖苷 质子 信号传送通路 TDAG8 psychosine proton signalling pathway
分类号 Q257 [生物学—细胞生物学]
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同被引文献8

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  • 6Mogi C,Tobo M,Tomura H. Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages[J].Journal of Immunology,2009,(05):3243-3251.
  • 7Ihara Y,Kihara Y,Hamano F. The G protein-coupled receptor T-cell death-associated gene 8(TDAG8) facilitates tumor development by serving as an extracellular pH sensor[J].Proceedings of the National Academy of Sciences(USA),2010,(40):17309-17314.
  • 8包良,王蕾,阿拉坦高勒.质子感知受体与肿瘤发生和肿瘤转移之间的关系[J].中国生物化学与分子生物学报,2011,27(7):598-603. 被引量：8

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生命的化学
2011年 第3期

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