老年人轻度认知功能损害与代谢综合征关系

Association between metabolic syndrome and mild cognitive impairment among the elderly:a nested case-control study

目的探讨老年人轻度认知功能损害(MC I)发生与代谢综合征(MS)的关系。方法以2004-2005年贵州省贵阳市参加基线调查的≥60岁并且静脉取血完成全部生化检测的对象为研究队列,筛选随访期间发生MC I患者83例,在同一队列未发生MC I人群中,按年龄、性别和受教育程度1∶2匹配,进行巢式病例对照研究,分析MS、MS各组分及其不同组合对MC I发生风险的影响。结果高血糖(OR=2.9,95%CI=1.4～5.9)、高血压(OR=2.5,95%CI=1.3～4.8)和脂代谢紊乱(OR=2.2,95%CI=1.1～4.1)均使MCI发生的风险提高;MS组分任意2项组合(组合Ⅰ)类型、任意3项及以上组合(组合Ⅱ)类型的患者发生MC I的风险分别是正常者的2.3倍(95%CI=1.2～4.6),是仅有MS任意1项组分者的3.5倍(95%CI=1.7～7.5)。结论高血糖、高血压和脂代谢紊乱是MC I发生的危险因素。随着所含MS组分的增多,MC I发生的风险也明显增加。

Objective To study the association between metabolic syndrome（MS） and mild cognitive impairment（MCI） among the elderly.Methods A 1∶2 amatched nested case-control study was conducted among the old people aged 60 and over,who participated in 2004-2005 baseline survey and completed biochemical tests.The impact of MS and components of MS on the risk of developing MCI were analyzed after adjusting for age,gender,and education.Results Hyperglycemia（odds ratio=2.9,95% confidence interval：1.4-5.9）,hypertension（OR=2.5,95% CI：1.3-4.8）,hyperlipidemia（OR=2.2,95%CI：1.1-4.1） showed significant effects on the development of MCI.Compared with the baseline group（normal or with one component of MS）,the risk of MCI for groupⅠ（with any two components of MS） and group Ⅱ（with any three or more components of MS） were 2.3 folds（OR=2.3,95%CI：1.2-4.6） and 3.5 folds（OR=3.5,95%CI：1.7-7.5） higher,respectively.Conclusion Hyperglycemia,hypertension,and hyperlipidemia are risk factors of MCI.The risk of MCI increases among the old people with increased components of MS.