外加磁场对平阳霉素磁性微球体内分布影响的实验研究

Studies on Distribution of Magnetic bearing Microspheres in Rabbits

目的 :观察在外加磁场作用下 ,磁性平阳霉素微球 (MPMs)在体内分布情况。方法 :设定新西兰白兔头部为一靶区 ,外加磁场 ,经兔耳缘静脉注射 MPMs,观察 MPMs在体内分布情况。并观察外加磁场强度及时间对微球在靶区定位的影响。结果 :经外加磁场作用下的 MPMs有较好的靶向分布性 ,且与外加磁场作用的时间、强度相平行。结论 :MPMs可能是治疗海绵状血管瘤的较为理想剂型。

Objective: To evaluate the distribution of magnetic bearing microspheres (MPMs) in rabbits. Methods: The distribution of intravenously injected 99m Tc labelled MPMs in rabbits at different intervals of magnetic field applied and different magnetic field intensity was investigated by using an externally applied magnetic field and measuring the radio activity at the rabbit head and other organs. Results: MPMs have the properties of targeted distribution, as positive correlation between targetic radio activity and times and intensity of magnetic field.Conclusion: MPMs may be better used in the therapy of cavernous hemangiomas.