巨细胞病毒感染患儿56例的血液学改变和临床分析

Analysis of haematological change in 56 infant cases infected with cytomegalovirus

目的探讨巨细胞病毒感染对婴幼儿血液系统的损害。方法以ELISA法检测患儿血液CMV-IgM,对CMV-IgM阳性患儿并发血液系统损害的患儿进行回顾性分析。结果在发生血液学改变的56例患儿中,轻度贫血42例,中度贫血14例,网织红细胞升高的27例(48%),血小板减少的23例(41%),白细胞升高的(>10×109/L)13例(23%),白细胞降低的(<4×109/L)12例(21%),外周血出现异型淋巴细胞的5例(9%)。结论血液系统损害是巨细胞病毒感染的症状之一,使用更昔洛韦抗病毒治疗,血液系统损害也随之好转。

Aim To analyzed the haematological change in 56 infant cases with cytomegalovirus （CMV） infection. Methods The CMV-IgM antibody in 56 infant cases infected CMV were detected with ELISA and the haematological change in 56 infant cases infected with CMV were analysed,retrospectively. Results Mild anemia occurred to 42 cases and moderate anemia occurred to 14 cases. Reticulated corpuscles was increased in 27 cases （48%）,Platelet in 23 cases （41%）decreased,while white blood cell count inl3 cases（23%） increased and reduced in 12 cases（21%）, in addition,atypical lymphocytes in the peripheral blood were observed in 5 cases. Conclusions The damage ito the haematalogical system is one of the symptoms of CMV infection and the damage in the haematological system can be improved after antiviral treatment.