摘要
目的：回顾性分析３０ 例恶性肉芽肿放射治疗效果和与预后有关的因素。方法：自１９８１ 年１ 月～１９９１ 年１２ 月收治３０ 例恶性肉芽肿病人。全部患者采用６０ Ｃｏ 外照射， Ｄ Ｔ４０ ～７０ Ｇｙ／４ ～７ｗ 。１２ 例患者放疗前后服用环已亚硝脲１００ ～１２０ｍｇ 。结果：３ 年及５ 年生存率分别为６３ ．５ ％ （１９／３０） 和５３ ．２ ％（１６／３０） ，放疗剂量、病变侵及范围及有无持续发热是影响预后的重要因素。结论：放疗是恶性肉芽肿首选治疗方法，肿瘤量以５０ ～６０ Ｇｙ／５ ～６ｗ 为宜，化疗可改善症状但不提高远期生存率。
Objective:To retrospectively analyze the effect of radiotherapy for 30 cases of lethal midline granuloma and prognostic factors.Methods:From January 1981 to December 1991,30 cases of lethal midline granuloma were all trcatcd by 60 Co radiotherapy,the radiation dose was 40～70Gy for 4～7 weeks.100～120mg of CCNU had been given to 12 patients,before and after radiotherapy.Results:The 3 year survival rates were 63.5%(19/30),53.2%(16/30),respeclively.Prognoslic faclors were radiation dose,extent of invasion and continued fever.Conclusions:Radiotherapy is the first choice for lethal midline granuloma.The recommended dose is 50～60Gy for 5～6 weeks.Chemotherapy can improve the symptoms,but can not increase the survival rate.
