细胞粘附分子在大肠癌浸润转移中的表达及其临床意义

Expression and clinical significance of cell adhesion molecules in colorectal carcinoma invasion and metastasis

目的：研究细胞粘附分子（ＣＡＭｓ）在大肠癌浸润转移过程中的作用。方法：应用免疫组化ＬＳＡＢ法，检测ＣＡＭｓ家族ＣＥＡ，ＣＤ４４ｓ及ＣＤ４４ｖ９在正常肠上皮、大肠癌原发灶组织中表达的改变。结果：大肠癌细胞中ＣＡＭｓ的分布极性发生了明显改变；癌细胞的表达强度与正常肠上皮明显不同；在原发灶组中，ＣＥＡ和ＣＤ４４ｓ的表达呈显著正相关，ＣＤ４４ｖ９的表达与肿瘤的分化程度和Ｄｕｋｅｓ分期密切相关。结论：ＣＡＭｓ以分布极性的变动以及表达程度的改变影响着癌细胞的侵袭表型，在大肠癌浸润转移的过程中起着重要作用。ＣＤ４４ｓ和ＣＤ４４ｖ９有可能作为新的肿瘤标志物，用于癌症的辅助诊断或转移潜能的筛选。

Objective: To explore the effect of cell adhesion molecules(CAMs)in the process of tumor invasion and metastasis. Methods:Using immunohistochemical (LSAB)technique, CEA, CD44s and its variant CD44v9 were detected in different tissues from 38 patients with colorectal carcinoma(CC) and normal colorectal membrane. Results: Polar distribution of these CAMs was significantly changed. The expression intensity of these 3 CAMS in cancer cells was dramatically different from that of normal colorectal membrane. As to staining of primary CC on the 3 CAMs, CD44v9 was significantly different from different clinical/pathological factors such as differentiation degree and Dukes stage. Conclusion: CAMs may play an important role in the invasive and metastatic progression of CC. CD44s and CD44v9 may be taken as new clinical markers, which not only can helpful the early diagnosis of cancer, but also to the early detection of metastatic potential.