卵巢上皮性癌脑转移四例临床分析

Cerebral Metastases in Patients with Epithelial Ovarian Carcinoma

目的探讨卵巢上皮性癌脑转移的发生率、相关因素、诊断和治疗方法。方法分析１９８９年至１９９７年，卵巢上皮性癌１３２例，其中４例发生脑转移。结果脑转移发生率为３％，脑转移发生与晚期癌和肿瘤分化程度有关，与肿瘤病理类型无关。晚期患者接受肿瘤细胞减灭术和系统化疗后生存时间延长；出现腹腔外转移者，脑转移发生率增高。结论颅脑计算机体层摄影术和磁共振显像检查是确诊脑转移的重要手段。综合治疗包括手术、放疗、化疗和降颅压，可改善脑转移症状。

Objective To detect the rate of occurrence, the relevant factors ,the diagnosis and treatment of cerebral metastases in patients with epithelial ovarian carcinoma. Methods The clinical data were analyzed in 4 cases of cerebral metastases from 132 cases of epithelial ovarian carcinoma after treatment between 19891997. Results The rate of cerebral metastases was 3%. The related factors were advanced stage, and tumor cells differentiation, but no related with the histologic type. More cases of cerebral metastasis were found because of the prolonged survival after cytoreductive surgery and systemic chemotherapy as well as the extraabdominal metastasis. Conclusions Computed tomography and magnetic resonance imaging were the important diagnostic methods. Combined treatments including surgery, radiotherapy and chemotherapy can improve the patients status and prolong their lives.