摘要
目的:研究p16和Rb基因蛋白的表达与肺癌临床病理学特征的关系。方法:采用免疫组织化学方法对89例肺癌进行了p16和Rb蛋白的定位观察。结果:肺癌p16基因蛋白的总丢失率为472%(42/89),且与肺癌的组织学类型、淋巴结转移、临床病理分期有关。Rb基因蛋白的总丢失率为315%(28/89),与组织学类型有关。p16和Rb基因蛋白的表达存在着明显的互补性。结论:p16和Rb基因蛋白的丢失是肺癌发生发展中重要的分子事件,与细胞周期G1→S期的负反馈调节环路中断关系密切。
Purpose To study the expression of p16 and Rb gene proteins in primary lung cancers. Method Eightynine cases of lung cancer were observed by immunohistochemistry. Results The loss of p16 protein in lung cancers was related to histological type, lymph node metastasis and progressive stage, while the loss of Rb protein only to histological type. The inverse correlation of p16 and Rb gene expression in lung cancers was confirmed. Conclusion The loss of p16 or Rb gene protein is an important molecular event in lung cancers, and closely related to the block in the negative regulatory pathway of cell cycle.
出处
《临床与实验病理学杂志》
CAS
CSCD
1999年第3期199-201,I030,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
国家"九五"重点科技项目
国家自然科学基金