弥漫性肺间质疾病中医常见证候分布的文献研究

Literature study on Chinese medicine common syndromes of diffuse interstitial lung disease

目的:基于文献分析弥漫性肺间质疾病中医常见证候分布规律及特征。方法:从中国生物医学文献数据库、中国学术期刊全文数据库和中国中医药文献检索系统数据库,检索近15年相关文献,对合格文献86篇筛选整理规范名称,建立数据库,采用统计描述、Logistic回归和聚类分析方法进行研究。结果:弥漫性肺间质疾病的常见证候有血瘀证、痰湿(浊)阻肺证、痰瘀互结证、痰热壅肺证、肺肾气阴两虚证、肺肾气虚证、阴阳俱虚证。痰热壅肺、痰湿(浊)阻肺、肺肾气虚、阴虚内热、血瘀证的证候属性比较稳定。结论:弥漫性肺间质疾病的中医常见证候有痰热壅肺证、痰湿(浊)阻肺证等以及血瘀兼证,证候属性有一定规律性,血瘀证贯穿疾病整个病理过程,其统计及分析结果有待于进一步深入研究分析。

Objective： To analysis distribution regularity and characteristic of Chinese medicine common syndromes of diffuse interstitial lung disease（DILD） based on literature.Methods： Literatures were collected from CBM,CNKI and TCM database in the late 15 years.The name of the disease was filtered standardized,a database was established.Methods of statistical description,Logistic regression and Cluster-analysis were used to analyze data collected.Results： blood stasis syndrome and the pattern of phlegm-dampness obstructing the lung,retention of phlegm and blood stasis in the lung,phlegm-heat obstructing the lung,deficiency of lung-kidney qi and yin,lung-kidney qi deficiency,deficiency in both yin and yang were common syndromes of DILD.The Syndromes Character of phlegm-heat obstructing the lung,phlegm-dampness obstructing the lung,lung-kidney qi deficiency,lung-kidney qi deficiency and blood stasis syndrome were stable.Conclusion： The common syndromes of DILD were the pattern of phlegm-heat obstructing the lung,phlegm-dampness obstructing the lung,blood stasis syndrome and so on,they were of certain regularity.Blood stasis syndrome was present in the whole pathological process of DILD,that was to be proven by further experiments