肺纤维化中肺内细胞参与机制研究进展

Research progress of participation mechanism of lung cells in pulmonary fibrosis

肺纤维化发病机制包括3个主要环节：肺泡炎症和免疫反应；肺实质损伤；受损肺泡异常修复致肺纤维化。在肺纤维化病程中，肺内各种细胞均参与其中，了解其参与机制有助于探索治疗肺纤维化的潜在靶点。

The pathogenesis of pulmonary fibrosis includes three main processes： alveolar inflammation and immune response,lung parenchymal injury,and pulmonary fibrosis induced by abnormal repair of injured alveolar. All kinds of hmg cells are involved in the course of pulmonary fibrosis. Understanding the mechanisms will help to explore a potential target for treatment of pulmonary fibrosis.