血管内皮生长因子家族及其与肺纤维化关系被引量：1

Relationship of vascular endothelial growth factor family with lung fibrosis

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摘要血管内皮生长因子家族是近年发现的与血管内皮功能密切相关的一组生物活性物质。在内皮细胞的增殖、迁移、存活和血管通透性的维持，以及肿瘤生长转移、创伤组织修复、组织纤维化等多种生理和病理过程中发挥重要作用。文中将具与肺纤维化的关系作一综述。 Vascular endothelial growth factor family is a group of bioactive substances discovered in recent years,which is closely related to function of vascular endothelium. It plays an important role in the proliferation, migration, and survival of endothelial cells,maintenance of vascular permeability, growth and metastasis of tumor, repair of wound tissue, fibrosis, and other physiological and pathological processes. This paper reviews the relationship of vascular endothelial growth factor family with pulmonary fibrosis.

作者何秋颖谢敏

机构地区四川大学华西医院呼吸内科

出处《国际呼吸杂志》 2011年第12期936-940,共5页 International Journal of Respiration

关键词血管内皮生长因子肺纤维化低氧 Vasqular endothelial growth factor Pulmonary fibrosis Hypoxia

分类号 R563.9 [医药卫生—呼吸系统]

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1Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 1989,246 : 1306-1309.
2Zygalaki E, Kaklamanis L, Nikolaou NI, et al. Expression profile of total VEGF, VEGF splice variants and VEGF receptors in the myocardium and arterial vasculature of diabetic and non.diabetic patients with coronary artery disease. Clin Biochem, 2008,41 : 82-87.
3Jeltsch M, Kaipainen A, Joukov V, et al. Hyperplasia of lymphatic vessels in VEGF C transgenic mice. Science, 1997, 276:1423-1425.
4Karkkainen MJ, Haiko P, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol, 2004,5 : 74-80.
5Das S, Ladell DS, Podgrabinska S,et al. Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases. Cancer Res, 2010,70 :1814-1824.
6Chien MH, Ku CC, Johansson G,et al. Vascular endothelial growth factor-C ( VEGF-C ) promotes angiogenesis by induction of COX 2 in leukemic cells via the VEGF R3/JNK/ AP-1 pathway. Carcinogenesis, 2009,30 : 2005- 2013.
7Wang ZG, Purl TS, Quigg RJ. Characterization of novel VEGF (vascular endothelial growth factor )-C splicing isoforms from mouse. Biochem J, 2010,428 :347-354.
8()rlandini M, Spreafico A, Bardelli M, et al. Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiation. J Biol Chem, 2006, 281:17961-17967.
9Kholovd I, Koota S, Kaskenpfifi N, et al. Adenovirus- mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle. Hum Gene Ther, 2007,18 :232-244.
10Song M, Yang H, Yao S, et al. A critical role of vascular endothelial growth factor D in zebrafish embryonic vasculogenesis and angiogenesis. Biochem Biophys Res Commun, 2007,357 : 924-930.