乳腺癌转移抑制基因1抑制肿瘤转移的机制

Mechanism of inhibition of tumor metastasis by breast cancer metastasis suppressor 1

乳腺癌转移抑制基因1（BRMS1）具有抑制肿瘤细胞转移的能力，可明显减少转移灶的发生，但不影响肿瘤的生长。其作用机制复杂，与细胞间通讯、磷酸肌醇信号转导以及与转录核因子-kB（NF—kB）的相互作用等有关。故探讨BRMS1抑制肿瘤转移的机制，希望用于肿瘤基因治疗。

Breast cancer metastasis suppressor 1 （BRMS1） can suppress the tumor cells metastasis, and significantly reduces the metastasis without affecting tumor growth. The relevant mechanism （s） may be related to intercellular communication, phosphoinositide signal transduction and interaction with NF-kB, and so on. Therefore, exploring the mechanisms of inhibition of tumor metastasis might be helpful for use of BRMS1 as tumor gene therapy.