短的上腭、肺及鼻咽上皮克隆1与耳鼻咽喉科疾病
被引量:1
摘要
短的上腭、肺及鼻咽上皮克隆1(short palate lung and nasal epithelium clone 1,是近年发现的一个特异性表达在呼吸道的天然免疫分子,其结构与杀菌/渗透性增加蛋白(bactericidal/permeability increasing protein, BPI)相似,且具有明显的疏水性,在免疫防御中发挥着重要的作用,参与对外界刺激的反应,与耳鼻咽喉科多种疾病包括感染、变态反应和肿瘤等相关。本文将对SPLUNC1在耳鼻咽喉科的新进展做一综述。
出处
《国际耳鼻咽喉头颈外科杂志》
2011年第4期219-222,共4页
International Journal of Otolaryngology-Head and Neck Surgery
参考文献25
-
1Weston WM, Leclair EE, Trzyna W, et al. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem, 1999, 274 (19) : 13698-13703.
-
2Bingle CD, Craven CJ. PLUNC: A novel family of candidate host defence proteins expressed in the upper airways andnasopharynx. Human Molecular Genetics, 2002, 11 (8) : 937-943.
-
3Di YP, Harper R, Zhao YH, et al. Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. JBiol Chem, 2003, 278 (2) : 1165-1173.
-
4Campos MA, Abreu AR, Nlend MC, et al. Purification and characterization of PLUNC from human- tracheobronchial secretions. Am J Respir Cell Mol Biol, 2004, 30 (2) .. 184-192.
-
5Kim CH, Kim K, Kim H J, et al. Expression and regulation of PLUNC in human nasal epithelium. Acta Oto-'Laryngulogica, 2006, 126 (10) : 1073-1078.
-
6Bingle L, Cross SS, High AS, et al. SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype. J Pathol, 2005, 205 (4) : 491-497.
-
7Ghafouri B, Stahlbom B, Tagesson C, et al. Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics, 2002, 2 (1) : 112-120.
-
8Lindahl M, Stahlbom B, Tagesson C. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization- time offlight. Electrophoresis, 2001, 22 (9) .. 1795-1800.
-
9Zhou HD, Fan SQ, Zhao J, et al. Tissue distribution of the secretory protein, SPLUNC1, in the human fetus. Histochem CellBiol, 2006, 125 (3) : 315-324.
-
10Zhang BC, Nie XM, Xiao BY, et al. Identification of tissue- specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray. Genes Chromosomes Cancer, 2003, 38 (1) : 80-90.
二级参考文献23
-
1周后德,李小玲,李桂源.新的天然免疫保护分子——PLUNC家族蛋白[J].生物化学与生物物理进展,2004,31(9):767-771. 被引量:9
-
2贺广湘,孙虹,王天生,李萃,刘火旺,陈玉.鼻息肉病与正常鼻黏膜组织的蛋白质组差异分析[J].临床耳鼻咽喉科杂志,2006,20(5):212-216. 被引量:4
-
3吴敏曼,孙虹,贺广湘,王天生,肖志强,冯雪萍.慢性鼻-鼻窦炎鼻息肉与正常鼻黏膜差异蛋白质的检测及其意义[J].中华耳鼻咽喉头颈外科杂志,2006,41(3):171-175. 被引量:6
-
4UNERI C, OZTURK O, POLAT S, et al. Determination of reactive oxygen species in nasal polyps[J].Rhinology, 2005,43:185-189.
-
5KARLIDAG T, IIHAN N, KAYGUSUZ I, et al. Roles of free radicals, nitric oxide, and scavenging enzymes in nasal polyp development[J]. Ann Otol Rhinol Laryngol, 2005,114:122- 126.
-
6BINGLE C D, CRAVEN C J. PLUNC: a novel family of candidate host defence proteins expressed in the airways and nasopharynx[J]. Hum Mol Genet,2002, 11:937-943.
-
7GHAFOURI B, KIHLSTROM E, TAGESSON C, et al. PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide [J]. Biochim Biophys Acta,2004,1699:57-63.
-
8SUNG Y K, MOON C, YOO J Y, et al. Plunc, a member of the secretory gland protein family, is upregulated in nasal respiratory epithelium after olfactory bulbectomy[J].J Biol Chem, 2002,277:12762- 12769.
-
9LINDAHL M, STAHLBOM B, TAGESSON C. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight[J]. Electrophoresis, 2001,221:1795 - 1800.
-
10TSUTSUMI ISHII Y, NAGAOKA I. Modulation of human beta-defensin-2 transcriptionin pulmonary epithelial cells by lipopolysaccharide stimulated mononuclear phagocytes via proinflammatory cytokine produetion[J].J Immunol, 2003,170:4226-4236.
共引文献12
-
1李友忠,卢永德,葛圣雷.鼻内镜术后布地奈德对术腔恢复及术腔黏膜修复过程的影响[J].现代中西医结合杂志,2008,17(34):5264-5266. 被引量:7
-
2吴敏曼,孙虹,刘火旺,王庭阔,李昌琪,刘丹.超氧化物歧化酶和PLUNC蛋白在慢性鼻窦炎和鼻息肉组织中的表达及意义[J].临床耳鼻咽喉头颈外科杂志,2008,22(20):913-916. 被引量:6
-
3章锦秀,李嘉宁.慢性鼻-鼻窦炎患者症状积分与病情的相关性研究[J].现代医院,2011,11(8):25-26. 被引量:2
-
4王瑢,何英.PLUNC蛋白在炎症反应中的作用及机制[J].国际耳鼻咽喉头颈外科杂志,2012,36(2):81-84. 被引量:1
-
5时纳.功能性鼻窦内窥镜术后术腔黏膜修复的研究[J].基层医学论坛,2012,16(28):3709-3710. 被引量:2
-
6周伟强.PLUNC家族蛋白与宿主早期抗感染防御作用[J].沈阳医学院学报,2012,14(4):193-195. 被引量:1
-
7李智林,王斌全.Toll样受体4在慢性鼻-鼻窦炎伴鼻息肉组织中的研究进展[J].实用医技杂志,2014,21(3):278-279. 被引量:2
-
8高诚凯,张丹梅,杨萍萍.腭 肺及鼻咽上皮克隆蛋白和Toll样受体-4在鼻息肉组织中的表达及相关性分析[J].中国药物与临床,2014,14(7):879-881. 被引量:2
-
9肖二彬.IL-9在慢性鼻-鼻窦炎合并鼻息肉患者中的检测及意义[J].中国中西医结合耳鼻咽喉科杂志,2015,23(2):128-129. 被引量:4
-
10张晓丽,高宝德,刘海燕,杜智慧,王继雪,孙延鸣.重组SPLUNC1抑菌及调节NE活性的研究[J].中国预防兽医学报,2016,38(10):823-826. 被引量:1
同被引文献17
-
1肖丁良,钟礼立,梁沫,黄寒,朱翠明,游晓星,彭力,谢乐云.肺炎支原体脂质膜蛋白诱导人支气管上皮细胞SPLUNC1的表达[J].医学临床研究,2013,30(6):1041-1045. 被引量:2
-
2陶岳,李新萍,剡根强,张孝恩,林为民.新疆石河子地区湖羊传染性胸膜肺炎流行病学调查研究及预防控制效果的初步研究[J].中国畜牧兽医,2006,33(2):62-65. 被引量:20
-
3Weston W M, Leclair E E, Trzyna W, et al. Differential dis play identification of plunc, a novel gene expressed in em- bryonic palate,nasal epithelium,and adult lung [J]. Journal of Bioiogical Chemistry, 1999,274(19) : 13698-13703.
-
4Bingle C D, Bingle I. Characterisation of the human plunc gene,a gene product with an upper airways and nasopha- ryngeal restricted expression pattern [J]- Bioehimica et Bio- physica Acta (BBA)-Gene Structure and Expression,2000, 1493(3) :363-367.
-
5Bingle L, Barnes F A, Cross S S, et al. Differential epithelial expression of the putative innate immune molecue SPLUNC1 in Cystic Fibrosis [J]. Respiratory Research, 2007,8:79.
-
6Bingle C D,Craven C J. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx[J]. Human Molecular Genetics, 2002,11 (8) : 937-943.
-
7Tsou Y A, Peng M T, Wu Y F, et al. Decreased PLUNC ex- pression in nasal polyps is associated with multibacterial colonization in chronic rhinosinusitis patients [J]. European Archives of Oto Rhino Laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Socie- ties,2014,271(2) :299-304.
-
8Chu H W, Thaikoottathil J, Rino J G, et al. Function and regulation of SPLUNC1 protein in mycoplasma infection and allergic inflammation [J]. Journal of Immunology, 2007,179(6) :3995-4002.
-
9Seshadri S,Lin D C,Rosati M,et al. Reduced expression of antimierobial PLUNC proteins in nasal polyp tissues of pa tients with chronic rhinosinusitis [J]. Allergy, 2012,67 (7) : 920-928.
-
10Thaikoottathil J V, Martin R J, Di P Y, et al. SPLUNC1 Deficiency Enhances Airway Eosinophilic Inflammation in Mice [J]. American Journal of Respiratory Cell and Molec- ular Biology,2012,47(2) :253-260.
-
1史剑波,李祖望,李华斌.变应性鼻炎的发病机制研究进展[J].中国医学文摘(耳鼻咽喉科学),2010,25(4):181-184. 被引量:4
-
2钟诚.怎样治疗过敏性鼻炎[J].家庭医药(就医选药),2012(1):32-33.
-
3祝威,汪欣,崔香艳,杜宝东.杀菌-通透性增强蛋白对大鼠中耳上皮细胞形态学的影响[J].中国耳鼻咽喉头颈外科,2004,11(6):383-385. 被引量:4
-
4黎众魁,姚开泰.应用改良的mRNA差异展示法克隆人鼻咽上皮特异性表达的cDNA片段[J].生命科学研究,1998,2(3):182-188.
-
5李学佩.阻塞性睡眠呼吸暂停综合征发病机制与治疗[J].中华医学信息导报,2005,20(23):15-16.
-
6黎众魁,许亮国,姚开泰.人胚鼻咽上皮发育分化与c-erbB-2的表达变化[J].生命科学研究,1998,2(4):268-272.
-
7周丽媛,王斌全,张芩娜.阻塞性睡眠呼吸暂停低通气综合征患者软腭组织病理学[J].国际耳鼻咽喉头颈外科杂志,2007,31(5):260-262. 被引量:1
-
8赵海亮,周才杰,赵九洲,曾宪海,李娟娟.杀菌-通透性增强蛋白对分泌性中耳炎大鼠水通道蛋白和黏蛋白表达的影响[J].中国耳鼻咽喉头颈外科,2013,20(4):200-203. 被引量:4
-
9脑袋圆者爱打呼噜[J].保健医苑,2004(5):56-56.
-
10Khoo Boo Chai.Proboscis lateralis-a short review[J].整形再造外科杂志,2004(2):65-67.