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短的上腭、肺及鼻咽上皮克隆1与耳鼻咽喉科疾病 被引量：1

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摘要 短的上腭、肺及鼻咽上皮克隆1（short palate lung and nasal epithelium clone 1,是近年发现的一个特异性表达在呼吸道的天然免疫分子，其结构与杀菌／渗透性增加蛋白（bactericidal/permeability increasing protein, BPI）相似，且具有明显的疏水性，在免疫防御中发挥着重要的作用，参与对外界刺激的反应，与耳鼻咽喉科多种疾病包括感染、变态反应和肿瘤等相关。本文将对SPLUNC1在耳鼻咽喉科的新进展做一综述。
作者 刘娟 王德辉
机构地区 复旦大学附属眼耳鼻喉科医院耳鼻咽喉科
出处 《国际耳鼻咽喉头颈外科杂志》 2011年第4期219-222,共4页 International Journal of Otolaryngology-Head and Neck Surgery
关键词 短的上腭 肺及鼻咽上皮克隆l(short PALATE lung and nasal epithelium clone 1) 免疫 天然(Immunity Natural) 耳鼻咽喉科学(Otolaryngology)
分类号 R739.63 [医药卫生—肿瘤]
  • 相关文献

参考文献25

  • 1Weston WM, Leclair EE, Trzyna W, et al. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem, 1999, 274 (19) : 13698-13703.
  • 2Bingle CD, Craven CJ. PLUNC: A novel family of candidate host defence proteins expressed in the upper airways andnasopharynx. Human Molecular Genetics, 2002, 11 (8) : 937-943.
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二级参考文献23

  • 1周后德,李小玲,李桂源.新的天然免疫保护分子——PLUNC家族蛋白[J].生物化学与生物物理进展,2004,31(9):767-771. 被引量：9
  • 2贺广湘,孙虹,王天生,李萃,刘火旺,陈玉.鼻息肉病与正常鼻黏膜组织的蛋白质组差异分析[J].临床耳鼻咽喉科杂志,2006,20(5):212-216. 被引量：4
  • 3吴敏曼,孙虹,贺广湘,王天生,肖志强,冯雪萍.慢性鼻-鼻窦炎鼻息肉与正常鼻黏膜差异蛋白质的检测及其意义[J].中华耳鼻咽喉头颈外科杂志,2006,41(3):171-175. 被引量：6
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  • 8SUNG Y K, MOON C, YOO J Y, et al. Plunc, a member of the secretory gland protein family, is upregulated in nasal respiratory epithelium after olfactory bulbectomy[J].J Biol Chem, 2002,277:12762- 12769.
  • 9LINDAHL M, STAHLBOM B, TAGESSON C. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight[J]. Electrophoresis, 2001,221:1795 - 1800.
  • 10TSUTSUMI ISHII Y, NAGAOKA I. Modulation of human beta-defensin-2 transcriptionin pulmonary epithelial cells by lipopolysaccharide stimulated mononuclear phagocytes via proinflammatory cytokine produetion[J].J Immunol, 2003,170:4226-4236.

共引文献12

同被引文献17

  • 1肖丁良,钟礼立,梁沫,黄寒,朱翠明,游晓星,彭力,谢乐云.肺炎支原体脂质膜蛋白诱导人支气管上皮细胞SPLUNC1的表达[J].医学临床研究,2013,30(6):1041-1045. 被引量：2
  • 2陶岳,李新萍,剡根强,张孝恩,林为民.新疆石河子地区湖羊传染性胸膜肺炎流行病学调查研究及预防控制效果的初步研究[J].中国畜牧兽医,2006,33(2):62-65. 被引量：20
  • 3Weston W M, Leclair E E, Trzyna W, et al. Differential dis play identification of plunc, a novel gene expressed in em- bryonic palate,nasal epithelium,and adult lung [J]. Journal of Bioiogical Chemistry, 1999,274(19) : 13698-13703.
  • 4Bingle C D, Bingle I. Characterisation of the human plunc gene,a gene product with an upper airways and nasopha- ryngeal restricted expression pattern [J]- Bioehimica et Bio- physica Acta (BBA)-Gene Structure and Expression,2000, 1493(3) :363-367.
  • 5Bingle L, Barnes F A, Cross S S, et al. Differential epithelial expression of the putative innate immune molecue SPLUNC1 in Cystic Fibrosis [J]. Respiratory Research, 2007,8:79.
  • 6Bingle C D,Craven C J. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx[J]. Human Molecular Genetics, 2002,11 (8) : 937-943.
  • 7Tsou Y A, Peng M T, Wu Y F, et al. Decreased PLUNC ex- pression in nasal polyps is associated with multibacterial colonization in chronic rhinosinusitis patients [J]. European Archives of Oto Rhino Laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Socie- ties,2014,271(2) :299-304.
  • 8Chu H W, Thaikoottathil J, Rino J G, et al. Function and regulation of SPLUNC1 protein in mycoplasma infection and allergic inflammation [J]. Journal of Immunology, 2007,179(6) :3995-4002.
  • 9Seshadri S,Lin D C,Rosati M,et al. Reduced expression of antimierobial PLUNC proteins in nasal polyp tissues of pa tients with chronic rhinosinusitis [J]. Allergy, 2012,67 (7) : 920-928.
  • 10Thaikoottathil J V, Martin R J, Di P Y, et al. SPLUNC1 Deficiency Enhances Airway Eosinophilic Inflammation in Mice [J]. American Journal of Respiratory Cell and Molec- ular Biology,2012,47(2) :253-260.

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国际耳鼻咽喉头颈外科杂志
2011年 第4期

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