中药注射剂不良反应的常见原因分析

目的探讨临床应用中药注射剂不良反应(ADR)的常见原因,提高临床用药安全。方法回顾性分析自2007年3月～2010年5月132例应用中药注射剂发生不良反应患者的临床资料,并对发生原因进行统计学分析。结果本组病例以30～60岁之间患者最多;ADR累及器官以皮肤系统、胃肠系统、神经系统最为常见(分别占31.1%、24.2%、18.2%),3种器官损害占73.5%,较其他器官损害明显为多(P<0.01),具有统计学意义;药证不符因素为引起中药注射液ADR的重要原因,其次为配伍失误、应用时间过长,三者占全部原因的77.2%,较其他因素明显为高(P<0.01),具有统计学意义。结论中药注射剂不良反应在临床较为常见,提高临床用药水平、注意中药的辨证论治、注意输液反应可以降低中药注射剂不良反应的发生率,提高用药安全。

Objective To study the clinical application of adverse reactions（tcmi obtains the common cause,improve） clinical drug safety. Methods Retrospective since March 2007～2010 application may occur in 132 cases tcmi clinical data of adverse reactions patients,and the statistical analysis of causes. Results All cases with 30 to 60 years old between most cases;obtains in skin system,involving the organs gastrointestinal system,nervous system is the most common（31.1%,innovation,which hold 18.2%） ,three organ damage,with other organs of 73.5% for damages significantly（P〈0.01） ,significant;Medicine syndrome caused by factors of traditional Chinese medicine injection,not the important reason,then obtains compatibility blunders,application for a long time,three of the total reason 77.2% than other factors,is apparently tall（P〈0.01） ,has a statistical significance. Conclusion Tcmi clinical relatively common adverse reactions in improving clinical medicine,traditional Chinese medicine,pay attention to the level of the syndrome differentiation and treatment,pay attention to the infusion reaction can reduce the incidence of adverse reactions tcmi,improve drug safety.