微创手术联合祛邪开窍法治疗脑出血的临床研究

目的探讨祛邪开窍法对脑出血患者血肿清除术后疗效与血浆内皮素(ET)水平的影响。方法将70例接受血肿微创清除术的患者随机分成治疗组和对照组,对照组采用内科综合治疗;治疗组在基础治疗上加用祛邪开窍法方药。于治疗前及治疗14d、30d时记录两组患者神经功能缺损程度评分进行对比,同时对比两组综合临床疗效;并于治疗后3d、7d、14d时检测血浆ET含量进行对比。结果两组治疗14d后,治疗组神经功能缺损程度评分及综合疗效优于对照组,差异有统计学意义(P<0.05);治疗30d后治疗组神经功能缺损程度评分及综合疗效优于对照组,两组比较差异有显著性统计学意义(P<0.01)。同时治疗组治疗后3d、7d、14d血浆ET含量均显著低于对照组(P<0.01)。结论脑出血患者血肿清除术合用祛邪开窍法方药可以降低血浆ET水平,促进神经功能康复,提高临床疗效。

Objective To investigate the Quxie Resuscitation of the hematoma after intracerebral hemorrhage in patients with efficacy and plasma endothelin（ET） levels. Methods 70 patients underwent minimally invasive removal of hematoma were randomly divided into treatment group and control group and the control group were treated with combined therapy internal medicine,treatment group in the basic treatment plus Quxie Resuscitation and formulas. Before treatment and treatment of 14d,30d when the two groups neurologic deficit scores were compared,and integrated clinical efficacy compared two groups,and after treatment 3d,7d,14d when the plasma ET levels were compared. Results 14d after treatment,the treatment group neurological deficit scores and the consolidated effective than the control group,the difference was statistically significant（P〈0.05） ,the treatment group after 30d degree of neurological deficit score and consolidated effective than the control group,the difference was significant statistically significant（P〈0.01） . At the same time after treatment,3d,7d,14d plasma ET levels were significantly lower than the control group（P〈0.01） . Conclusion The cerebral hemorrhage hematoma combined Quxie Resuscitation medicine can reduce plasma ET levels,and promote recovery of neural function and improve clinical efficacy.