人类白细胞抗原DR分子和细胞间粘附分子1在正常和病变角膜的表达及意义

Expression and significance of human leukocyte antigen DR and intercellular adhesion molecule 1 in normal and pathological corneas

目的 探讨正常及病变角膜中人类白细胞抗原ＤＲ 分子和细胞间粘附分子１ 的表达及其在角膜炎症和移植排斥反应中的作用和影响。方法 应用免疫组化技术对１０ 例正常人及４８ 例患者的病变角膜标本进行人类白细胞抗原ＤＲ分子和细胞间粘附分子１ 的表达的检测。结果 正常人角膜无或轻微表达人类白细胞抗原ＤＲ 分子和细胞间粘附分子１ ；病变角膜，尤其是炎症角膜及角膜移植术后发生排斥反应的角膜，其阳性表达率明显增高。结论 人类白细胞抗原ＤＲ 分子和细胞间粘附分子１ 的异常表达与角膜炎性反应有关。

Objective To study the expression of human leukocyte antigen DR (HLA DR) and intercellular adhesion molecule 1 (ICAM 1) in normal and pathological corneas and their significance in corneal inflammation and rejection after keratoplasty Methods The expression of HLA DR and ICAM 1 were detected in 10 normal corneas and 48 pathological corneas by using immunohistochemical techniques Results HLA DR and ICAM 1 were not expressed or only slightly expressed in normal corneas and markedly expressed in pathological corneas, especially in inflammatory corneas In general, HLA DR and ICAM 1 were co expressed in similar regions The expression rates of HLA DR and ICAM 1 in the 7 cases of keratoplasty rejection were higher than that in the 21 cases of non rejection Conclusion The overexpression of HLA DR and ICAM 1 is related to corneal inflammation and can promote the occurrence of keratoplasty rejection