截瘫后下肢神经病理改变的初步研究

Nerve degeneration of lower extremity after paraplegia

目的：了解截瘫后下肢神经的病理改变。方法：（１） 将实验犬的脊髓从 Ｔ１１～１２平面完全横断，分别于第３，６ 周取出下肢主要神经干，切片、染色后，光镜下观察神经纤维形态学改变；（２） 在给陈旧性截瘫患者行肋间神经转位、腓肠神经移植桥接马尾手术的同时，切取腓肠神经行病理切片检查。结果： 实验犬的下肢神经未见明显变性，截瘫患者的腓肠神经组织形态基本正常。结论： Ｔ１１以上脊髓损伤截瘫后，下肢神经无明显变性。

Objective: To study the nerve degeneration of lower extremity after paraplegia. Methods: (1) The spine cord of experimental dogs were severed between T 11~12 . The section of main nerve trunks of lower extremities were studied under microscope after 3~6 weeks; (2) the sural nerve of later paraplegic patients were analyzed. Results: No obvious degeneration was found in the nerve of lower extremities of experimental dogs and later paraplegic patients. Conclusion: No obvious degeneration is found in lower extremity nerve if the injury plane is higher than T 11 .