n-3多不饱和脂肪酸与骨代谢

N-3 polyunsaturated fatty acids and bone metabolism

骨质疏松是当今老龄社会的主要健康和经济问题,影响人类生活质量和寿命,基因因素、脂肪酸营养摄入等影响骨质疏松及其并发症。脂肪酸是细胞膜的重要组成部分,通过调节钙吸收、破骨细胞形成、前列腺素的合成、细胞膜n-6/n-3脂肪酸比率、细胞因子及脂质过氧化等可影响骨代谢。本文综述了膳食中n-3脂肪酸的重要性及fat-1基因对骨代谢的影响,n-3脂肪酸影响人类和鼠的骨代谢,分析n-3脂肪酸对骨代谢影响的细胞与分子机制。

Osteoporosis is a major problem of public health and economy in the aged society today, which affects the life equality and life span of human being. The genetic factors and fatty acid nutritional intake affect osteoporosis and its complication. Fatty acids are important ingredients of the cell membrane. The bone metabolism can be affected by the regulation of calcium absorption, formation of osteoelasts, the synthesis of prostagladin, the ratio of n-6/n-3 fatty acids on the cell membrane, the cytokines, and peroxidation of the fat. This paper reviews the importance of dietary n-3 fatty acids and the effect of fat-1 gene on bone metabolism. N-3 polyunsaturated fatty acids affect bone metabolism of the human and the rat. The paper analyzes the cellular and molecular mechanism of the effect of n-3 polyunsaturated fatty acids on bone metabolism.