关于肝癌发生相关基因的研究进展

Research progress on liver cancer related gene

我国肝癌的发病率位居全球首位,在各种癌症的病死率中,肝癌排列第二位(仅次于胃癌),而且大多肝癌病例发现较晚,治疗成本高昂且效果差。近年来乙型、丙型和丁型肝炎病毒已被证实会增加肝癌发生的几率,尤其是前两者在我国的肝癌患者中检出率很高。随着分子生物学的发展,基因水平的预测和诊断肝癌技术越来越受到全世界的关注,肝癌多态性,易感性及候选基因也成为探究的新靶点。本文着重介绍了这些国内外基因和信号途径的目前研究情况,进一步的探究与肝癌的发病机理之间的联系。

China has the highest risk of HCC in the world. Among all kinds of cancers, HCC ranks the second （after stomach cancer）, and most of them have come to the end when found, with high treatment cost and low effect. Recently, HBV, HCV and HDV have been confirmed to increase the risk of HCC, especially HBV and HCV. With the development of molecule biochemistry, anticipation and diagnosis technology in gene level of HCC is becoming more and more attraction. HCC＇s SNPs, susceptibility and candidate gene has become new treating target. This review puts emphasis on genes and signal pathways researched in and out of the country. To further research the relation between them with the pathology of HCC.