新生儿缺氧缺血性脑病血清心肌损伤标志物检测分析及临床意义

Clinical significance and testing analysis on the landmark of myocardial damage of newborns' serum of anoxic ischemic encephalopathy

目的探讨心肌损伤标志物对诊断新生儿缺氧缺血性脑病(HIE)患者心肌损伤的临床意义。方法对不同程度HIE患儿和健康新生儿(对照组)分别测定血清cTnI、CK-MB和Mb浓度。结果 3组HIE患儿心肌损伤标志物均增高,其中以重度患儿最高,中度患儿次之,轻度患儿增高较少。组间比较差异均有统计学意义(P<0.05)。HIE患儿出生第1天均以Mb异常率最高,3d后Mb均持续下降,阳性持续时间短,而CK-MB和cTnI却升至峰值,并维持在较高水平达1周以上。结论 HIE患儿脑损伤越重,心肌损伤也越重;联合检测心肌损伤标志物有利于心肌损伤的早期诊断、程度评估及预后判断。

Objective To probe the clinical significance of the myocardium damage landmark of HIE on the diagnosis. Methods According to different levels of HIE newborns and healthy ones, measure serum eTnI, CK - MB and Mb. Re- suits Landmarks of the myocardium damage in HIE patients are mounting up among three groups. The highest - lever patients list number one and the minor, the less. The differences among groups are statistical significant （P 〈 0. 05 ）： bib of HIE newborns is the highest for the first day and then declineing 3 days later. So time of being positive is short. Howerver, CK - MB and cTnl maintain are at higher levels over one week. Conclusion The more serious the brain damage of HIE newborns, the more seriuos the myocardium damage is ; Jointing detection of landmark of myocardium damage has benifits to the early diagnosis, evaluation and predicting prognosis.