氟康唑综合疗法治疗37例复发性念珠菌性外阴阴道炎的疗效观察及分析

Curative effect observation and analysis of 37 cases of recurrent vulvo vaginal candidiasis treating with fluconazole combination therapy

目的探讨复发性念珠菌性外阴阴道炎的治疗及预防。方法按治疗方法不同分为两组,治疗组给予氟康唑150 mg/d,同时联合应用抗组胺药如西替利嗪10 mg/d,乙酰水杨酸片0.3 mg/d,连服6 d,以后续用3个月经周期各6 d;非月经期间外用硼酸胶囊600 mg/晚。对照组选用氟康唑150 mg/d,共6 d。治疗3个月后观察疗效。结果两组治疗后1周的治愈率并无显著差异,治疗组为97.3%,对照组为89.66%;但治疗后3个月复查,治疗组复发率为0,对照组则为17.24%。治疗后6个月复查,治疗组复发率为5.56%,而对照组的复发率为34.48%,两组在3、6个月复发率的比较,差异均有统计学意义。结论氟康唑综合短程冲击治疗加月经期间断性、预防性给药对复发性念珠菌性外阴阴道炎的治疗和预防效果显著。

Objective To investigate recurrent vulvo vaginal candidiasis treatment and prevention. Methods To observe the two groups of patients,fluconazole in the experiment - group given 150 mg/clay,at the same time the joint application, such as antihistamines eetirizine 10 mg/ day of aeetylsalicylie acid tablets 0. 3 g / day, even the 6 - day service to, after three months of follow - up with the 6 - day cycle ; non - menstrual period for external use boric acid capsules of 600 mg / night. In the control -group selection of fluconazole 150 mg/ day, a total of 6 days. 3 months after the treatment effect observed. Results The two groups after 1 week of treatment did not cure a significant difference in the treatment group for 97. 3 percents, to 89. 66 percents in the control group ; but after treatment in March to review the treatment group relapse rate of O, control group compared with 19. 23 percents. After treatment for 6 months to review the treatment group relapse rate was 5.56 percents, while the control group, the recurrence rate was 38.46 percents, the two groups in the 3 months to 6 months, the recurrence rate of its differences comparison are significant. Conclusion The flueonazole comprehensive treatment increases the impact of short - range off during the period of preventive administration of recurrent vulvo vaginal eandidiasis in the treatment and prevention have a better effect.