螺内酯治疗心力衰竭的临床研究

Clinical experience of spironolactone in the treatment of heart failure

目的观察螺内酯在心衰治疗中的作用。方法将70例高血压心衰患者,随机分成治疗组(n=35)和对照组(n=35),分别进行心功能分级和6 min步行试验。对照组采用基础治疗(吸氧、半坐卧位、依那普利、倍他乐克、极化液,体液潴留明显者给予速尿20 mg/d等),治疗组在此基础上加用螺内酯40 mg/d,两组均治疗8周,观察两组治疗后总有效率(心功能改善和6 min试验变化情况)。结果与对照组比较,治疗组心功能有明显改善,总有效率显著提高。治疗组总有效率91.43%,对照组总有效率74.29%,两组比较差异有统计学意义(P<0.05)。结论螺内酯在基础治疗的基础上,对心衰患者有明显治疗作用。

Objective To observe the splronolaetone in the treatment of heart failure. Methods 70 patients with hypertensive heart failure were randomly divided into treatment group （n = 35 ） and the control group （n = 35 ） functional class, respectively, and 6min walk test. Control group based therapy （ oxygen, half sitting and lying position, enalapril, metoprolol, polarized liquid, fluid retention were given furosemide was 20 rag/d, etc）, treatment group was added on top of spirenolactone 40 rag/d, both groups were treated for 8 weeks after treatment, the total effective rate （6 min test heart function improvement and change ）. Results Compared vdth control group, treatment group had signifeantly improved heart funetlon, significantly improved overall CtFlciency, the efficiency of the treatment group was 91.43% in the control group, the total efficiency of 74.29%. The difference between the two groups was significant （ P 〈 0.05 ）. Conclusion The treatment of spironolaetone on the basis of the basis of heart failure patients have significant therapeutic effect.