退行性视网膜病变中睫状神经营养因子神经保护作用的研究进展

Neuroprotection of retinal degenerative disease by ciliary neurotrophic factor

多项体内外及临床试验结果均证实睫状神经营养因子（CNTF）对光感受器细胞具有良好的神经保护作用，同时也对视网膜多种神经细胞的结构和功能产生不同的影响。CNTF对光感受器细胞保护作用的分子机制涉及Stat、Erk及Akt等信号传导途径，其中Miiller细胞发挥着重要作用。细胞包囊技术为CNTF提供了有效的给药途径，在多种退行性视网膜病变的动物模型中均取得良好疗效，其临床应用中的安全性和有效性正在进行评估，这将为CNTF进入临床应用奠定基础。

Ciliary neurotrophic factor （CNTF） has been showing neuroprotective effects on photoreceptors in a variety of in vivo and in vitro experiments and clinical trials. CNTF causes morphological and functional alterations in various retinal nerve cells. The neuroprotection mechanism of CNTF involves STAT-dependant, ERK-dependant, and Akt-dependant signaling pathways, in which M^iller cells play an important role. Encapsulated cell technology （ECT） device is an efficient administration approach to deliver CNTF into the eyes, which is effective in retarding photoreceptor degeneration in several animal models with retinal degenerative diseases. The safety and efficiency of the device in clinical trials are also being evaluated currently for further clinical use in human eyes as a potential treatment.