妊娠中晚期急性EB病毒感染的临床研究

The clinical pathological analysis Of Epstein-Barr virus active infection during the middle-late pregnancy

目的探讨EB病毒急性感染与胎儿水肿的关系，了解妊娠中晚期EB病毒感染对母儿的危害及妊娠结局的影响。方法对孕期B超检查符合胎儿水肿综合征的40例孕妇作为研究组，进行孕妇血清EBEA-IgM检测，观察妊娠结局，并随机抽取同期101例胎儿正常的孕妇血作为对照组。结果研究组孕妇EBEA-IgM阳性率（95％）显著高于对照组（48．5％，P〈0．01），且死胎、活产、胎儿异常引产的比例与对照组相比差异有统计学意义（P〈0．01），活产中早产（40％）率明显高于对照组（10．9％，P〈0．05）。结论孕期急性EB病毒感染与胎儿水肿的发生存在相关性，应重视孕期EB病毒感染的检测。

Objective To explore the relationship of acute infections of Epstein-Barr virus and bydrops fetalis and explore the harm to fetuses and the affection on pregnancy outcomes caused by acute EBV infection during pregnancy. Methods 40 eases hydrops fetalis were diagnosed by ultrasonography. The difference between the EBEA-IgM positive and negative patients blood were studied. 101 cases over the same period of pregnant women with normal fetuses were enrolled as a control group. Results The positive rate of EBEA-IgM in pregnant women （95%） was significantly higher than that of control group（48. 5%, P 〈 O. 01 ）. And the differences of the ratio of still birth and live birth and abnormal fetuses induction of labor between the groups were statistically significant（ P 〈 0. 01 ）. Premature birth among the live birth （40%） was obviously higher than that of control group （ 10. 9% , P 〈 0. 05 ）. Conclusions Active infection of EBV in pregnancy was relevant to the hydrops fetalis and there need to pay attention to the detection of EBV during pregnancy.