诱骗受体3在食管鳞癌中的表达及其与肿瘤浸润T细胞的关系

Expression of decoy receptor 3 in esophageal squamous cell carcinoma and its correlation with tumor infiltrating T lymphocytes

目的探讨诱骗受体3(DcR3)在食管鳞癌中的表达、临床病理意义及与肿瘤浸润T细胞(TIL)的关系。方法采用免疫组化SABC法检测60例食管鳞癌中DcR3的表达情况及TIL的分布、数量,分析DcR3与各临床病理因素及与TIL的关系。结果 DcR3在食管鳞癌组织的表达率高于正常组织(P<0.05)。DcR3表达与食管鳞癌的分化程度和浸润深度相关(P<0.05),而与年龄、性别、肿瘤大小和有无淋巴结转移无相关性(P>0.05)。DcR3表达阳性肿瘤组织中的TIL数少于表达阴性肿瘤者(P<0.05)。结论 DcR3在食管鳞癌中的异常表达,可能通过阻断细胞凋亡和逃避免疫监视等作用促进肿瘤发生发展,检测DcR3表达有助于判断食管鳞癌的恶性程度。

Objective To investigate expression of decoy receptor 3 （ DcR3 ） in esophageal squamous cell carcinoma （ESCC） and to explore its correlation with tumor infiltrating T lymphocytes （TIL）. Methods Expressions of DcR3 and TIL were detected in lesions of ESCC （ n = 60） by SABC immunohistochemistry. An analysis was performed to search for a possible correlation between DcR3 expression and clinicopathological factors including TIL. Results Exlxession of DcR3 was higher in ESCC than in normal tissues （P 〈 0.05）. Further, expression of DcR3 was related to the tumor＇ s state of differentiation and infiltration depth （ P 〈 0.05 ）, but not to the age, sex, tumor size, lymph nodes metastasis and pathological type （ P 〉 0.05）. The average number of TIL was smaller in ESCC with positive DcR3 expression than in that with negative expression （P 〈 0.05 ）. Conclusion Elevated expression of DcR3 in ESCC might promote tumor genesis and progression by blocking apoptosis and evading the immune surveillance. The detection of DcR3 expression is indicative of the malignance of ESCC.