河南省18岁以下人群甲型H1N1流感抗体水平调查分析

Levels of the antibody to swine-origin influenza A(H1N1) virus in the population under 18 years in Henan Province

目的了解河南省18岁以下人群甲型H1N1流感抗体水平,为甲流防控提供相关依据。方法采用微量血凝抑制试验对国家卫生部"甲型H1N1流感血清学横断面调查"的2 020人(≤18岁)进行甲型H1N1流感抗体水平检测。结果 河南省18岁以下人群血清抗体阳性率为29.60%,13～18岁、7～12岁、0～6岁阳性率分别为45.70%、25.67%、23.71%,各年龄组阳性率比较差异有统计学意义(χ2=80.07,P<0.01)。城乡有差异(郑州市35.47%、其他市36.00%、农村23.67%)。接种疫苗人群抗体水平(63.89%)显著高于未接种人群(25.91%),χ2=117.18,P<0.01;有无流感样症状者的抗体阳性率差异无统计学意义(χ2=0.75,P>0.01)。结论 18岁以下人群具有一定的甲型H1N1流感抗体,但抗体水平较低,人群普遍易感,建议提高甲型H1N1流感疫苗接种率,进一步加强甲型H1N1流感防控措施。

Objective To detect levels of the antibody to swine-origin influenza A（H1 N1 ） virus in the population under 18 years in Henan Province, and to provide data for a new preventive policy on swine-origin influenza A（ H1N1 ） virus. Methods A total of 2 020 residents under 18 years, involved in a research program of the Ministry of Health named as ＂Cross-sectional study of swine-origin influenza A （H1N1） influenza infection situation＂, were surveyed and a blood test with routine micro-hem agglutination inhibition test was done. Results The positive rate of the antibody in the population under 18 years was 29.60%, and the rates in the three age groups were 45.70% （ 13-18 years）, 25.67% （7-12 years） and 23.71% （0-6 years）, respectively. There were statistically significant differences among the three groups （X^2 =80.07, P 〈0.01 ）. Positive rates of the antibody in the three areas showed differences（35.47% in the provincial capital, 36.00% in other cities and 23.67% in the rural area）. The positive rate of the antibody in the vaccinated population （63.89%） was significantly higher than in the unvaccinated population（25.91% ） （X^2 = 117. 18, P 〈 0.01 ）. There was no significant difference between people with symptoms of influenza-like illness （ILI） and people without（x^2 = 0. 75, P 〉 0.01 ）. Contusion Levels of the antibody to swine-origin influenza A （ H1N1 ） virus are low in the population under 18 years in Henan Province. Strengthening vaccination and improving treatment of children are recommended strategies for swine-origin influenza A （HIN1） virus control and prevention.