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原发性胆汁性肝硬化的治疗进展 被引量：10

Therapy advances in primary biliary cirrhosis
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摘要 原发性胆汁性肝硬化(PBC)是一种慢性肝内胆汁淤积性疾病。熊去氧胆酸(UDCA)是惟一经随机对照临床试验证实的治疗PBC安全有效的药物。经UDCA治疗1年后有较好生化应答的患者,其长期预后较好。目前,对UDCA应答欠佳患者的治疗方法尚不确定。肝移植是治疗终末期PBC患者惟一有效的方法。 Primary biliary cirrhosis（PBC） is a chronic intrahepatic cholestatic disease.Ursodeoxycholic acid（UDCA） is the only safe and effective drug for the treatment of PBC proven by randomized controlled clinical trials.Favorable long-term effects of UDCA are observed in patients with good biochemical response after one year treatment.There is currently no consensus on how to treat patients with a suboptimal biochemical response to UDCA.Liver transplantation is the only therapeutic option for end-stage patients
作者 段维佳 尤红
机构地区 首都医科大学附属北京友谊医院肝病中心
出处 《临床肝胆病杂志》 CAS 2011年第6期581-583,共3页 Journal of Clinical Hepatology
关键词 肝硬化 胆汁性 liver cirrhosis, biliary
分类号 R575.2 [医药卫生—消化系统]
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参考文献23

  • 1Lindor KD, Gershwin ME, Poupon R, et al. Primary biliary cirrhosis[J]. Hepatology, 2009, 50(1): 291-308.
  • 2European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. [J]. J Hepatol, 2009, 51(2): 237-267.
  • 3Pares A, Caballeria L, Redes J, et al. Excellent long-term sur- vival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic Acid[J]. Gastroenterology, 2006, 130(3): 715-720.
  • 4Corpechot C, Chazouilleres O, Poupon R, et at. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis[J]. Hepatology, 2008, 48(3): 87I -887.
  • 5Kuiper EM, Hansen BE, de Vrios RA, et al. Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxychohc acid[J]. Gastroenterology, 2009, 136(4): 1281-1287.
  • 6Babatin MA, Sanai FM, Swain MG. Methotrexate therapy for the symptomatic treatment of primary biliary cirrhosis patients, who are biochemical incomplete responders to ursodeoxychoiic acid therauv[J]. Aliment Pharmacol Ther, 2006, 24(5): 813-820.
  • 7Bonis PA, Kaplan M. Methotrexate improves biochemical tests in patients with primary biliary cirrhosis who respond incompletely to ursodiol[J]. Gastroenterology. 1999, 117(2): 395-399.
  • 8Kaplan MM, Bonder A, Ruthazer R, et al, Methotrexate in patients with primary biliary cirrhosis who respond incompletely to treatment with ursodeoxycholic acid[J], Dig Dis Sci, 2010,55(11): 3207-3217.
  • 9Rautiainen H, Karkkainen P, Karvonen AL, et al. Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial[J]. Hepatology, 2005, 41(4): 747-752.
  • 10Rabahi N, Chretien Y, Gaouar F, et al. Triple therapy with ursodeoxycholic acid, budesonide and mycophenolate mofetil in patients with features of severe primary biliary cirrhosis not responding to ursodeexycholic acid alone[J]. Gastroenterol Clin Biol, 2010, 34(4): 283-287.

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临床肝胆病杂志
2011年 第6期

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