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关于短期抗甲状腺药物治疗与抗中性粒细胞胞浆抗体关系的研究

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摘要 目的探讨甲状腺功能亢进症(简称甲亢)患者治疗前后抗中性粒细胞胞浆抗体(ANCA)检出情况及其与短期抗甲状腺药物治疗的关系。方法将60例初诊Graves病甲亢患者治疗前作为未治疗组(n=60),治疗后归为治疗组(n=10),40例非甲亢健康人群作为对照组(n=40)。用间接免疫荧光法(IIF)检测血清ANCA及抗核抗体(ANA)。结果 2例初诊未治疗甲亢患者ANCA-IIF阳性,10例治疗前ANCA阴性患者药物治疗6个月后及健康人群未检测出ANCA,患者与健康人群差异无统计学意义(P>0.05)。所有血清ANA均阴性。结论 ANCA与Graves病本身可能无关,以及短期抗甲状腺药物治疗可能不诱发ANCA。
作者 谭艳华 刘惠平 罗艳华
机构地区 吉林市医院内分泌科 吉林省地方病第二防治研究所
出处 《中国地方病防治》 2011年第3期235-236,共2页 Chinese Journal of Control of Endemic Diseases
关键词 甲状腺功能亢进症 抗体 抗核 甲状腺拮抗药
分类号 R581.1 [医药卫生—内分泌]
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参考文献11

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二级参考文献7

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中国地方病防治
2011年 第3期

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