急性心肌梗死血清白细胞介素-6、10水平与心功能研究

The study of serum interleukin-6 and interleukin-10 and heart function of patients with acute myocardial infarction

目的:观察急性心肌梗死(AMI)合并心力衰竭(心衰)患者血清白细胞介素(IL)-6、10对心功能的影响。方法:选择AMI患者(AMI组)30例于发病后24 h检测血清IL-6、IL-10。在心肌梗死后2周内观察心功能,心脏超声心动图检查测定左室射血分数(EF)、左室短轴缩短率(FS)、等容舒张期时间(IVRT)。结果:AMI合并心衰组血清IL-6水平及IL-6/IL-10比值高于未合并心衰组,分别是IL-6:[(306.35±131.32)∶(198.59±52.08)ng/L,P<0.05]、IL-6/IL-10比值:[(18.18±12.66)∶(11.49±7.47),P<0.05]。相关分析:IL-6、IL-10与IVRT呈正相关(r=0.624、r=0.297,P<0.05),与EF(r=-0.559、r=-0.364,P<0.05)、FS(r=-0.453、r=-0.324,P<0.05)呈负相关,IL-6与心功能分级呈正相关(r=0.540、r=0.0.085,P<0.05)。结论:AMI合并心衰时IL-6水平增高更为显著,IL-6/IL-10比值增大。

Objective：To investigate the effect of serum interleukin-6（IL-6）,interleukin-10（IL-10） on cardiac function in patient with acute myocardial infarction（AMI）.Method：Thirty AMI patients were enrolled and 6 mlblood sample were taken at 24hs after AMI to measure the levels of IL-6 and IL-10.Ejection fraction（EF）,fractional shortening of left ventricle（FS） and isovolumetric relaxation time（IVRT） were measured with echocardiography to evaluate the cardiac function two weeks after AMI.Result：Serum levels of IL-6 and the ratio of IL-6/IL-10 in cardiac failure group were significantly higher than those in tnon cardiac failure group [IL-6,（306.35±131.32）∶（198.59±52.08）pg/ml,P0.05];[the ratio of IL-6/IL-10,（18.18±12.66）∶（11.49±7.47）,P0.05].IL-6 and IL-10 were positively correlated with IVRT,but negatively correlated with EF and FS.Conclusion：In patients with cardiac failue after AMI,serum IL-6 was significantly increased and the ratio of IL-6/IL-10 was increased also.